Map2k4 Gene Summary [Mouse]
Predicted to enable JUN kinase kinase activity and molecular adaptor activity. Involved in intrinsic apoptotic signaling pathway in response to hydrogen peroxide and smooth muscle cell apoptotic process. Acts upstream of or within MAPK cascade; negative regulation of motor neuron apoptotic process; and response to wounding. Predicted to be located in axon; dendrite cytoplasm; and perikaryon. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian serous carcinoma; pancreatic cancer; respiratory system cancer (multiple); and urinary bladder cancer. Orthologous to human MAP2K4 (mitogen-activated protein kinase kinase 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Map2k4 |
| Official Name | mitogen-activated protein kinase kinase 4 [Source:MGI Symbol;Acc:MGI:1346869] |
| Ensembl ID | ENSMUSG00000033352 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase kinase 4 |
| Synonyms | JNKK, JNKK1, MAPK/ERK KINASE-1, MAPKK4, MEK4, mitogen-activated protein kinase kinase 4, MKK4, PRKMK4, SAPKK-1, SEK1, SERK1, SKK1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Map2k4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein threonine/tyrosine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- subdomain of kinase domain
- catalytic domain
- ATP-binding domain
- Protein tyrosine and serine/threonine kinase
- JUN kinase kinase
- protein binding
- Protein kinase domain
- MEKK1 binding domain
- phosphorylation site
- kinase
- MAP kinase kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- docking domain
- Protein Kinases, catalytic domain
- alcohol group acceptor phosphotransferase
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Map2k4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- 4-1BB Signaling in T Lymphocytes
- Agrin Interactions at Neuromuscular Junction
- Apelin Liver Signaling Pathway
- Apelin Pancreas Signaling Pathway
- B Cell Activating Factor Signaling
- CCR5 Signaling in Macrophages
- CD27 Signaling in Lymphocytes
- Ceramide Signaling
- CXCR4 Signaling
- ErbB Signaling
- Glucocorticoid Receptor Signaling
- HGF Signaling
- IL-17A Signaling in Airway Cells
- IL-17A Signaling in Gastric Cells
- IL-22 Signaling
- Induction of Apoptosis by HIV1
- Inhibition of Angiogenesis by TSP1
- LPS-stimulated MAPK Signaling
- Melatonin Signaling
- PAK Signaling
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Role of IL-17A in Arthritis
- Role of MAPK Signaling in the Pathogenesis of Influenza
- STAT3 Pathway
- Toll-like Receptor Signaling
- UVB-Induced MAPK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- advanced non-small cell lung cancer
- metastasis
- breast cancer
- neoplasia
- metastatic non-small cell lung cancer
- metastatic colon cancer
- colorectal carcinoma
- colorectal carcinomagenesis
- cardiac hypertrophy
- cutaneous melanoma
role in cell
- activation in
- proliferation
- expression in
- growth
- differentiation
- phosphorylation in
- apoptosis
- cell death
- molecular cleavage in
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- Nucleus
- Mitochondria
- cytosol
- neurites
- perikaryon
- axons
- dendrites
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Map2k4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to sorbitol
- signal transduction
- cellular senescence
- Fc-epsilon receptor signaling pathway
- response to wounding
- JNK cascade
- positive regulation of DNA replication
- smooth muscle cell apoptotic process
- cell growth involved in cardiac muscle cell development
- positive regulation of neuron apoptotic process
- MAPK cascade
- cellular response to mechanical stimulus
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of JNK cascade
- positive regulation of protein phosphorylation
- negative regulation of motor neuron apoptotic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- dendrite cytoplasm
- cytosol
- perikaryon
- axon
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein tyrosine kinase activity
- protein binding
- protein kinase activity
- protein serine/threonine kinase activity
- JUN kinase kinase activity
- binding, bridging