Rps7 Gene Summary [Mouse]
A structural constituent of ribosome. Acts upstream of or within neural crest cell differentiation and neural tube closure. Part of cytosolic small ribosomal subunit. Is active in synapse. Is expressed in brain; cerebral cortex ventricular layer; cortical plate; and pancreas epithelium. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 8. Orthologous to human RPS7 (ribosomal protein S7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rps7 |
| Official Name | ribosomal protein S7 [Source:MGI Symbol;Acc:MGI:1333818] |
| Ensembl ID | ENSMUSG00000061477 |
| Bio databases IDs | |
| Aliases | ribosomal protein S7 |
| Synonyms | DBA8, eS7, LOC497813, Mtu, ribosomal protein S7, Rps7A, S7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rps7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- mRNA 3' UTR binding
- structural constituent of ribosome
- mRNA 5' UTR binding
- enzyme inhibitor activity
- Ribosomal protein S7e
- protein binding
- enzyme regulator activity
- poly(U) binding protein
Pathways
Biological processes and signaling networks where the Rps7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diamond-blackfan anemia type 8
- metabolic syndrome X
- Diamond-Blackfan anemia
role in cell
- cell death
- expression in
- differentiation
- processing in
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- interchromatin granule cluster fractions
- pre-ribosome
- cellular membrane
- ribosome
- Nucleus
- centrosome
- Endoplasmic Reticulum
- cytosol
- nucleoplasm
- nucleoli
- synapse
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rps7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neural tube closure
- neural crest cell differentiation
- positive regulation of gene expression
- cytoplasmic translation
- ribosomal small subunit biogenesis
- rRNA processing
- protein stabilization
- translation
- negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- small-subunit processome
- cytosolic ribosome
- cytosolic small ribosomal subunit
- endoplasmic reticulum
- synapse
- nucleolus
- ribosome
- nucleoplasm
- nucleus
- centrosome
- focal adhesion
- cytoplasm
- membrane
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- RNA binding
- structural constituent of ribosome
- mRNA 5'-UTR binding
- mRNA 3'-UTR binding