RPS7 Gene Summary [Human]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
RPS7
Official Name
ribosomal protein S7 [Source:HGNC Symbol;Acc:HGNC:10440]
Ensembl ID
ENSG00000171863
Bio databases IDs NCBI: 6201 Ensembl: ENSG00000171863
Aliases ribosomal protein S7
Synonyms DBA8, eS7, LOC497813, Mtu, ribosomal protein S7, Rps7A, S7
Species
Human, Homo sapiens
OrthologiesMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RPS7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • protein kinase binding
  • mRNA 3' UTR binding
  • structural constituent of ribosome
  • mRNA 5' UTR binding
  • enzyme inhibitor activity
  • Ribosomal protein S7e
  • protein binding
  • enzyme regulator activity
  • poly(U) binding protein

Pathways

Biological processes and signaling networks where the RPS7 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • diamond-blackfan anemia type 8
  • metabolic syndrome X
  • Diamond-Blackfan anemia
regulated by
regulates
role in cell
  • cell death
  • expression in
  • differentiation
  • processing in
  • translation in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • interchromatin granule cluster fractions
  • pre-ribosome
  • cellular membrane
  • ribosome
  • Nucleus
  • centrosome
  • Endoplasmic Reticulum
  • cytosol
  • nucleoplasm
  • nucleoli
  • synapse
  • cytosolic fraction

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human RPS7 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • neural tube closure
  • neural crest cell differentiation
  • positive regulation of gene expression
  • cytoplasmic translation
  • ribosomal small subunit biogenesis
  • rRNA processing
  • protein stabilization
  • translation
  • negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Cellular Component

Where in the cell the gene product is active
  • small-subunit processome
  • cytosolic ribosome
  • cytosolic small ribosomal subunit
  • endoplasmic reticulum
  • synapse
  • nucleolus
  • ribosome
  • nucleoplasm
  • nucleus
  • centrosome
  • focal adhesion
  • cytoplasm
  • membrane
  • cytosol
  • macromolecular complex

Molecular Function

What the gene product does at the molecular level
  • protein kinase binding
  • protein binding
  • RNA binding
  • structural constituent of ribosome
  • mRNA 5'-UTR binding
  • mRNA 3'-UTR binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.