Med13l Gene Summary [Mouse]
Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within transcription by RNA polymerase II. Part of mediator complex. Is expressed in 1-cell stage embryo; 2-cell stage embryo; cortical plate; and primary oocyte. Human ortholog(s) of this gene implicated in dextro-looped transposition of the great arteries. Orthologous to human MED13L (mediator complex subunit 13L). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Med13l |
| Official Name | mediator complex subunit 13-like [Source:MGI Symbol;Acc:MGI:2670178] |
| Ensembl ID | ENSMUSG00000018076 |
| Bio databases IDs | |
| Aliases | mediator complex subunit 13-like |
| Synonyms | 2210413I17Rik, 6330591G05Rik, 9030618F05Rik, KIAA1025, mediator complex subunit 13L, mediator complex subunit 13-like, mKIAA1025, MRFACD, PROSIT240, THRAP2, TRAP240L |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Med13l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription co-activator
- MID domain of medPIWI
- Mediator complex subunit 13 C-terminal domain
Pathways
Biological processes and signaling networks where the Med13l gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hereditary disorder
- d-transposition of the great arteries
- mental retardation and distinctive facial features with or without cardiac defects
- pervasive developmental disorder
- mental retardation and distinctive facial features without cardiac defects
- global developmental delay
- mental retardation
- mental retardation and distinctive facial features with cardiac defects
- neurodevelopmental disorder
- chromatinopathy
role in cell
- proliferation
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Med13l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- mediator complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription cofactor activity