Myt1l Gene Summary [Mouse]
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in negative regulation of transcription by RNA polymerase II; neuron development; and neuron fate specification. Located in nucleus. Is expressed in several structures, including eye; genitourinary system; nervous system; and olfactory epithelium. Used to study autosomal dominant intellectual developmental disorder 39. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 39. Orthologous to human MYT1L (myelin transcription factor 1 like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Myt1l |
| Official Name | myelin transcription factor 1-like [Source:MGI Symbol;Acc:MGI:1100511] |
| Ensembl ID | ENSMUSG00000061911 |
| Bio databases IDs | |
| Aliases | myelin transcription factor 1-like |
| Synonyms | 2900046C06RIK, 2900093J19RIK, C630034G21Rik, LOC102724128, mKIAA1106, MRD39, myelin transcription factor 1-like, NZF1, Nztf1, Pmng1, Png-1, ZC2H2C2, ZC2HC4B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Myt1l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- transcription co-activator
- nucleic acid binding
- Zinc finger, C2HC type
- protein binding
- sequence-specific DNA binding
- transition metal ion binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- Myelin transcription factor 1
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- zinc ion binding
- double-stranded DNA binding
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- attention deficit hyperactivity disorder
- obesity
- autism
- autosomal dominant mental retardation type 39
- mental retardation
- non-insulin-dependent diabetes mellitus
- organismal death
- psoriasis
- muscle weakness
role in cell
- expression in
- maturation
- differentiation
- development
- generation
- commitment
- transdifferentiation
- conversion
- transactivation in
- specification
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Myt1l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- neuron fate specification
- neuron differentiation
- neuron fate commitment
- nervous system development
- neuron development
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- DNA binding
- zinc ion binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity