Ppp4r3a Gene Summary [Mouse]
Predicted to enable protein phosphatase activator activity. Acts upstream of or within positive regulation of gluconeogenesis and protein dephosphorylation. Located in cytoplasm and nucleus. Part of protein phosphatase 4 complex. Is expressed in several structures, including central nervous system; heart; and retina nuclear layer. Orthologous to human PPP4R3A (protein phosphatase 4 regulatory subunit 3A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppp4r3a |
| Official Name | protein phosphatase 4 regulatory subunit 3A [Source:MGI Symbol;Acc:MGI:1915984] |
| Ensembl ID | ENSMUSG00000041846 |
| Bio databases IDs | |
| Aliases | protein phosphatase 4 regulatory subunit 3A |
| Synonyms | 1110034C04Rik, FLFL1, KIAA2010, mKIAA2010, MSTP033, PP4R3, PP4R3A, protein phosphatase 4 regulatory subunit 3A, protein phosphatase 4, regulatory subunit 3A, RGD1309059, SMEK1, smk-1, UOEH-LC-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ppp4r3a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Phosphatase 4 regulatory subunit 3
- protein binding
- Pleckstrin homology-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- lung cancer
- nonalcoholic steatohepatitis
- Hutchinson-Gilford progeria syndrome
- lung squamous cell carcinoma
- squamous cell lung cancer
- familial thyroid gland non-medullary carcinoma
- familial nonmedullary thyroid cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
regulated by
- B lymphocytes
role in cell
- expression in
- proliferation
- phosphorylation in
- number
- migration
- activation in
- invasion by
- colony formation by
- gluconeogenesis in
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- Nucleus
- cytosol
- nucleoplasm
- nuclear speckles
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ppp4r3a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein dephosphorylation
- response to DNA damage stimulus
Cellular Component
Where in the cell the gene product is active
- centrosome
- nuclear speck
- cytosol
- protein phosphatase 4 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein phosphatase activator activity