Lancl2 Gene Summary [Mouse]
Predicted to enable phosphatidylinositol-3-phosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylinositol-5-phosphate binding activity. Predicted to be involved in negative regulation of DNA-templated transcription and positive regulation of abscisic acid-activated signaling pathway. Predicted to be located in cortical actin cytoskeleton; cytosol; and nucleoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including gut; lung; male reproductive gland or organ; nervous system; and sensory organ. Orthologous to human LANCL2 (LanC like glutathione S-transferase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lancl2 |
| Official Name | LanC (bacterial lantibiotic synthetase component C)-like 2 [Source:MGI Symbol;Acc:MGI:1919085] |
| Ensembl ID | ENSMUSG00000062190 |
| Bio databases IDs | |
| Aliases | LanC (bacterial lantibiotic synthetase component C)-like 2 |
| Synonyms | 1700003F10RIK, GPR69B, LanC (bacterial lantibiotic synthetase component C)-like 2, LanC like glutathione S-transferase 2, LOC103695213, TASP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lancl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Lanthionine synthetase C-like protein
- Cyclases involved in the biosynthesis of lantibiotics, and similar proteins
- protein binding
- phosphatidylinositol binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cortical actin cytoskeleton
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lancl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- negative regulation of transcription, DNA-dependent
- peptide modification
- positive regulation of abscisic acid mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- cortical actin cytoskeleton
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- GTP binding
- phosphatidylinositol-4-phosphate binding
- ATP binding
- protein binding
- phosphatidylinositol-5-phosphate binding
- phosphatidylinositol-3-phosphate binding