LANCL2 Gene Summary [Human]
Enables phosphatidylinositol-3-phosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylinositol-5-phosphate binding activity. Involved in negative regulation of transcription, DNA-templated and positive regulation of abscisic acid-activated signaling pathway. Located in several cellular components, including cortical actin cytoskeleton; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | LANCL2 |
| Official Name | LanC like 2 [Source:HGNC Symbol;Acc:HGNC:6509] |
| Ensembl ID | ENSG00000132434 |
| Bio databases IDs | |
| Aliases | LanC like 2, LanC like glutathione S-transferase 2, testis-specific adriamycin sensitivity protein, G protein-coupled receptor 69B |
| Synonyms | 1700003F10RIK, GPR69B, LanC (bacterial lantibiotic synthetase component C)-like 2, LanC like glutathione S-transferase 2, LOC103695213, TASP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LANCL2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Lanthionine synthetase C-like protein
- Cyclases involved in the biosynthesis of lantibiotics, and similar proteins
- protein binding
- phosphatidylinositol binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cortical actin cytoskeleton
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LANCL2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- negative regulation of transcription, DNA-dependent
- peptide modification
- positive regulation of abscisic acid mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- cortical actin cytoskeleton
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- GTP binding
- phosphatidylinositol-4-phosphate binding
- ATP binding
- protein binding
- phosphatidylinositol-5-phosphate binding
- phosphatidylinositol-3-phosphate binding