Btbd9 Gene Summary [Mouse]
Involved in modulation of chemical synaptic transmission. Acts upstream of or within several processes, including circadian sleep/wake cycle, non-REM sleep; long-term memory; and multicellular organismal-level iron ion homeostasis. Is active in glutamatergic synapse. Is expressed in several structures, including early conceptus; genitourinary system; liver; retina nuclear layer; and telencephalon. Used to study restless legs syndrome. Orthologous to human BTBD9 (BTB domain containing 9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Btbd9 |
| Official Name | BTB (POZ) domain containing 9 [Source:MGI Symbol;Acc:MGI:1916625] |
| Ensembl ID | ENSMUSG00000062202 |
| Bio databases IDs | |
| Aliases | BTB (POZ) domain containing 9 |
| Synonyms | 1700023F20RIK, 4930402L05, BTB domain containing 9, dJ322I12.1, LOC100361081, LOC100362201 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Btbd9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- BTB And C-terminal Kelch
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- F5/8 type C domain
- BTB/POZ domain
- protein binding
- BACK (BTB and C-terminal Kelch) domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- metabolic syndrome X
- lung squamous cell carcinoma
- insomnia
- restless legs syndrome
- acute myeloid leukemia
- colorectal cancer
- squamous cell lung cancer
- sleep disorder
- periodic limb movement disorder
regulates
- 5-hydroxytryptamine
- dopamine
role in cell
- growth
- abnormal morphology
- paired-pulse facilitation
- plasticity
- endocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- glutaminergic synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Btbd9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- long-term memory
- serotonin metabolic process
- circadian sleep/wake cycle, non-REM sleep
- multicellular organismal iron ion homeostasis
- regulation of synaptic vesicle endocytosis
- regulation of synaptic transmission
- adult locomotory behavior
- circadian behavior
- sensory perception of temperature stimulus
Cellular Component
Where in the cell the gene product is active
- cytoplasm