Mlxipl Gene Summary [Mouse]
Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Contributes to DNA binding activity. Involved in glucose mediated signaling pathway; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and regulation of primary metabolic process. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is active in nucleoplasm. Is expressed in several structures, including central nervous system; gut; liver; metanephros; and nose. Used to study irritable bowel syndrome. Human ortholog(s) of this gene implicated in coronary artery disease and myocardial infarction. Orthologous to human MLXIPL (MLX interacting protein like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Mlxipl |
| Official Name | MLX interacting protein-like [Source:MGI Symbol;Acc:MGI:1927999] |
| Ensembl ID | ENSMUSG00000005373 |
| Bio databases IDs | |
| Aliases | MLX interacting protein-like |
| Synonyms | bHLHd14, CHREBP, MIO, MLX, MLX interacting protein-like, MONDOB, WBSCR14, WS-bHLH |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mlxipl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 14-3-3 binding domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- protein kinase binding
- nucleic acid binding
- basic Helix Loop Helix (bHLH) domain superfamily
- alpha helix
- nuclear localization sequence
- transcription factor binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- phosphorylation site
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- NES2-NLS_ChREBP-like
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- Mondo conserved region
- double-stranded DNA binding
- helix loop helix domain
- helix-loop-helix domain
- Helix-loop-helix DNA-binding domain
- transcription factor activity
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Mlxipl gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- weight loss
- hearing loss
- diabetes mellitus
- liver neoplasia
- liver cancer
- digestive system cancer
- abdominal cancer
- gout
- diarrhea
role in cell
- proliferation
- expression in
- accumulation in
- phosphorylation in
- glycolysis in
- lipogenesis in
- activation in
- cell death
- G1 phase
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mlxipl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of oxidative phosphorylation
- positive regulation of cell proliferation
- fatty acid homeostasis
- lipid biosynthetic process
- regulation of transcription, DNA-dependent
- anatomical structure morphogenesis
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter by glucose
- positive regulation of glycolysis
- regulation of transcription from RNA polymerase II promoter
- positive regulation of fatty acid biosynthetic process
- positive regulation of lipid biosynthetic process
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- glucose homeostasis
- negative regulation of peptidyl-serine phosphorylation
- energy homeostasis
- glucose mediated signaling pathway
- triglyceride homeostasis
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- cytoplasm
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein homodimerization activity
- protein heterodimerization activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- carbohydrate response element binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity