Pak1ip1 Gene Summary [Mouse]
Predicted to enable protein kinase inhibitor activity. Acts upstream of or within cell population proliferation and roof of mouth development. Located in nucleolus. Is expressed in several structures, including brain; chondrocranium; face; heart; and liver. Orthologous to human PAK1IP1 (PAK1 interacting protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pak1ip1 |
| Official Name | PAK1 interacting protein 1 [Source:MGI Symbol;Acc:MGI:1915333] |
| Ensembl ID | ENSMUSG00000038683 |
| Bio databases IDs | |
| Aliases | PAK1 interacting protein 1 |
| Synonyms | 5830431I15Rik, 5930415H02Rik, bA421M1.5, Gdpd1, hPIP1, MAK11, PAK1 interacting protein 1, PIP1, Riken cDNA 5830431i15, WDR84 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pak1ip1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Anaphase-promoting complex subunit 4 WD40 domain
- WD40 repeats
- WD domain, G-beta repeat
- WD40
- protein binding
Pathways
Biological processes and signaling networks where the Pak1ip1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pak1ip1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- negative regulation of signal transduction
- ribosomal large subunit biogenesis
- palate development
Cellular Component
Where in the cell the gene product is active
- nucleolus
Molecular Function
What the gene product does at the molecular level
- protein binding