Ing2 Gene Summary [Mouse]
Predicted to enable DNA binding activity; methylated histone binding activity; and phosphatidylinositol binding activity. Involved in several processes, including male meiosis I; seminiferous tubule development; and spermatogenesis. Acts upstream of or within negative regulation of apoptotic signaling pathway and positive regulation of DNA-templated transcription. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of CCAAT-binding activity factor complex and Sin3-type complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and immune system. Orthologous to human ING2 (inhibitor of growth family member 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Ing2 |
| Official Name | inhibitor of growth family, member 2 [Source:MGI Symbol;Acc:MGI:1916510] |
| Ensembl ID | ENSMUSG00000063049 |
| Bio databases IDs | |
| Aliases | inhibitor of growth family, member 2 |
| Synonyms | 2810011M06Rik, ING1L, Ing2b, inhibitor of growth family member 2, inhibitor of growth family, member 2, P33ING2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ing2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone deacetylase regulator
- histone binding
- PHD zinc finger
- transcription regulator
- cysteine-rich zinc-binding domain
- protein binding activity, bridging
- chromatin binding
- Phosphatidylinositol binding domain
- protein binding
- phosphatidylinositol binding
- DNA binding
- binding protein
- Inhibitor of growth (ING) domain family
- PHD finger superfamily
- Inhibitor of growth proteins N-terminal histone-binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- globozoospermia
- hyperplasia
- oligozoospermia
- asthenozoospermia
- neoplastic histiocytosis
- hematologic cancer
- hematological neoplasia
- teratozoospermia
role in cell
- apoptosis
- expression in
- growth
- transcription in
- acetylation in
- production in
- number
- function
- formation
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasmic fraction
- nuclear matrix fraction
- Cytoplasm
- Plasma Membrane
- nuclear foci
- nucleoplasm
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ing2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of gene expression, epigenetic
- signal transduction
- spermatid development
- spermatogenesis
- male meiosis I
- regulation of transcription, DNA-dependent
- response to DNA damage stimulus
- negative regulation of transcription from RNA polymerase II promoter
- male germ-line stem cell division
- sperm motility
- seminiferous tubule development
- positive regulation of transcription, DNA-dependent
- negative regulation of cell migration
- regulation of cellular senescence
- negative regulation of transforming growth factor beta receptor signaling pathway
- positive regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- CCAAT-binding factor complex
- plasma membrane
- nucleoplasm
- Sin3-type complex
Molecular Function
What the gene product does at the molecular level
- histone deacetylase regulator activity
- DNA binding
- protein binding
- metal ion binding
- methylated histone residue binding
- phosphatidylinositol binding
- chromatin binding