Rbbp7 Gene Summary [Mouse]
Enables RNA binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of ESC/E(Z) complex and NuRD complex. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut; and sensory organ. Orthologous to human RBBP7 (RB binding protein 7, chromatin remodeling factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rbbp7 |
| Official Name | retinoblastoma binding protein 7, chromatin remodeling factor [Source:MGI Symbol;Acc:MGI:1194910] |
| Ensembl ID | ENSMUSG00000031353 |
| Bio databases IDs | |
| Aliases | retinoblastoma binding protein 7, chromatin remodeling factor |
| Synonyms | mRbAp46, RbAp46, Rb-associated protein p46, RBB7, RB binding protein 7, chromatin remodeling factor, retinoblastoma binding protein 7, chromatin remodeling factor, SPGFX9 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rbbp7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Histone-binding protein RBBP4 or subunit C of CAF1 complex
- histone binding
- transcription regulator
- WD40 repeats
- WD domain, G-beta repeat
- WD40
- protein binding
- RNA binding
Pathways
Biological processes and signaling networks where the Rbbp7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- cervical small cell carcinoma
- extrapulmonary small cell cancer
- epithelial uterine cancer
- cervical cancer
- prostatic carcinoma
- prostate cancer
- refractive error
role in cell
- growth
- expression in
- outgrowth
- transcription in
- destruction in
- remodeling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytosol
- nucleoplasm
- telomeres
- chromatin
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rbbp7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell fate specification
- DNA replication
- regulation of transcription, DNA-dependent
- brain development
- response to steroid hormone stimulus
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- cellular heat acclimation
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- negative regulation of cell growth
- regulation of stem cell differentiation
- negative regulation of transforming growth factor beta receptor signaling pathway
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome, telomeric region
- ESC/E(Z) complex
- NuRD complex
- histone deacetylase complex
- cytosol
- NURF complex
- nucleoplasm
- Sin3-type complex
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- histone binding