Sinhcaf Gene Summary [Mouse]
Involved in negative regulation of cell differentiation and positive regulation of cell population proliferation. Predicted to be located in nucleus. Predicted to be part of Sin3-type complex. Is expressed in several structures, including central nervous system; early embryo; gut; heart; and lung. Orthologous to human SINHCAF (SIN3-HDAC complex associated factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sinhcaf |
| Official Name | SIN3-HDAC complex associated factor [Source:MGI Symbol;Acc:MGI:1929091] |
| Ensembl ID | ENSMUSG00000039985 |
| Bio databases IDs | |
| Aliases | SIN3-HDAC complex associated factor |
| Synonyms | C12orf14, FAM60A, L4, LOC100909791, PPCS1, Pptcs1, SIN3-HDAC complex associated factor, TERA |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sinhcaf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein Family FAM60A
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- organismal death
- hypoplasia
- non-small cell lung cancer
- growth failure
- ventricular septal defect
- transposition of great vessel
- colorectal adenoma
- colorectal adenoma formation
- double outlet right ventricle
role in cell
- expression in
- quantity
- migration
- differentiation
- proliferation
- apoptosis
- gemcitabine sensitivity
- ferroptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- myelin enriched fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sinhcaf gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of cell differentiation
- positive regulation of cell proliferation
- negative regulation of cell migration
- negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- Sin3-type complex
Molecular Function
What the gene product does at the molecular level
- protein binding