Ap1g2 Gene Summary [Mouse]

This gene encodes the gamma-2 subunit of the adaptor protein complex 1 (AP-1). AP-1 complex is a heterotetramer comprised of two heavy and one each of medium and small subunits. The encoded protein is a heavy subunit of AP-1 complex that regulates polarized sorting of cargo at the trans-Golgi network and endosomes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Details

Type
Nonsense Mediated Decay
Official Symbol
Ap1g2
Official Name
adaptor protein complex AP-1, gamma 2 subunit [Source:MGI Symbol;Acc:MGI:1328307]
Ensembl ID
ENSMUSG00000040701
Bio databases IDs NCBI: 11766 Ensembl: ENSMUSG00000040701
Aliases adaptor protein complex AP-1, gamma 2 subunit
Synonyms adaptor protein complex AP-1, gamma 2 subunit, adaptor protein complex AP-1, γ 2 subunit, adaptor related protein complex 1 subunit gamma 2, adaptor related protein complex 1 subunit γ 2, Adtg2, G2AD, LOC100362547
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ap1g2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • appendage domain
  • clathrin binding domain
  • ear domain
  • Adaptin C-terminal domain
  • ubiquitin binding domain
  • hinge domain
  • protein binding
  • Adaptin N terminal region

Pathways

Biological processes and signaling networks where the Ap1g2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • sudden cardiac arrest
  • infection by HIV-1
regulated by
regulates
role in cell
  • production in
  • morphology
  • degradation in
  • destruction in
  • budding in
  • reverse transcription in
  • size
  • reverse transcription

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • perinuclear region
  • cellular membrane
  • vesicles
  • Golgi Apparatus
  • ER-to-Golgi intermediate compartment
  • Golgi membrane
  • trans Golgi network
  • synapse
  • transport vesicles
  • perinuclear vesicles
  • Golgi cisternae
  • Golgi vesicles

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Ap1g2 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • vesicle-mediated transport
  • intracellular protein transport
  • Golgi to vacuole transport

Cellular Component

Where in the cell the gene product is active
  • membrane
  • AP-1 adaptor complex
  • Golgi apparatus
  • Golgi membrane
  • endosome membrane
  • transport vesicle
  • Golgi-associated vesicle

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • clathrin adaptor activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.