Grm3 Gene Summary [Mouse]
Enables calcium channel regulator activity and group II metabotropic glutamate receptor activity. Involved in postsynaptic modulation of chemical synaptic transmission. Acts upstream of or within gene expression. Located in several cellular components, including axon; dendritic spine; and postsynaptic density. Is active in glutamatergic synapse; postsynaptic membrane; and presynaptic membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and visual system. Orthologous to human GRM3 (glutamate metabotropic receptor 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Grm3 |
| Official Name | glutamate receptor, metabotropic 3 [Source:MGI Symbol;Acc:MGI:1351340] |
| Ensembl ID | ENSMUSG00000003974 |
| Bio databases IDs | |
| Aliases | glutamate receptor, metabotropic 3 |
| Synonyms | 0710001G23Rik, GLUR3, glutamate metabotropic receptor 3, glutamate receptor, metabotropic 3, Gmr3, GPRC1C, LOC689121, LOC689135, Metabotropic glutamate receptor 3, mGlu3, MGLUR3, Mglur group 3, mGluR III |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Grm3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Receptor family ligand binding region
- group II metabotropic glutamate receptor
- protein binding
- 7 transmembrane sweet-taste receptor of 3 GCPR
- seven-transmembrane G protein-coupled receptor superfamily
- glutamate receptor
- calcium channel regulator
- Type 1 periplasmic binding fold superfamily
- transmembrane domain
- Nine Cysteines Domain of family 3 GPCR
- cytosolic tail domain
- PDZ binding motif
Pathways
Biological processes and signaling networks where the Grm3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Breast Cancer Regulation by Stathmin1
- cAMP-mediated signaling
- Cellular Effects of Sildenafil (Viagra)
- CREB Signaling in Neurons
- FAK Signaling
- G-Protein Coupled Receptor Signaling
- Glutamate Receptor Signaling
- Gαi Signaling
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- Phagosome Formation
- Synaptic Long Term Depression
- Synaptic Long Term Potentiation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- schizophrenia
- bipolar disorder
- breast carcinoma
- cancer
- gastroesophageal reflux
- glioblastoma
- peripheral arterial disease
- melanoma
- melanoma cancer
role in cell
- phosphorylation in
- apoptosis
- growth
- cell death
- migration
- activity
- long-term potentiation
- depolarization
- response by
- action potential in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cell surface
- cellular membrane
- presynaptic membrane
- postsynaptic membrane
- dendritic spines
- neurites
- axons
- postsynaptic density
- axon terminals
- astrocyte projections
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Grm3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of adenylate cyclase activity
- adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
- gene expression
- synaptic transmission
- G-protein coupled glutamate receptor signaling pathway
- regulation of synaptic transmission, glutamatergic
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- postsynaptic density
- postsynaptic membrane
- dendritic spine
- axon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- group II metabotropic glutamate receptor activity
- G-protein coupled receptor activity
- scaffold protein binding
- glutamate receptor activity
- calcium channel regulator activity