Alg11 Gene Summary [Mouse]
Predicted to enable GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity. Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and respiratory system. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ip. Orthologous to human ALG11 (ALG11 alpha-1,2-mannosyltransferase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Alg11 |
| Official Name | asparagine-linked glycosylation 11 (alpha-1,2-mannosyltransferase) [Source:MGI Symbol;Acc:MGI:2142632] |
| Ensembl ID | ENSMUSG00000063362 |
| Bio databases IDs | |
| Aliases | asparagine-linked glycosylation 11 (alpha-1,2-mannosyltransferase) |
| Synonyms | AI849156, ALG11 alpha-1,2-mannosyltransferase, ALG11, alpha-1,2-mannosyltransferase, ALG11 α-1,2-mannosyltransferase, ALG11, α-1,2-mannosyltransferase, AW492253, B230397C21, CDG1P, GT8, LOC100505039, Mmat-4(5), RGD1564725 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Alg11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glycosyltransferase family 1 and related proteins with GTB topology
- glycolipid 2-alpha-mannosyltransferase
- enzyme
- protein binding
- ALG11 mannosyltransferase N-terminus
- Glycosyl transferases group 1
- alpha-1,2-mannosyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Alg11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oligosaccharide-lipid intermediate biosynthetic process
- protein N-linked glycosylation
- dolichol-linked oligosaccharide biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
Molecular Function
What the gene product does at the molecular level
- GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity
- alpha-1,2-mannosyltransferase activity