Hspbp1 Gene Summary [Mouse]
Predicted to enable adenyl-nucleotide exchange factor activity; molecular sequestering activity; and ubiquitin protein ligase binding activity. Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and positive regulation of protein ubiquitination. Predicted to be active in endoplasmic reticulum and extracellular space. Is expressed in dentate gyrus subgranular zone. Orthologous to human HSPBP1 (HSPA (Hsp70) binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hspbp1 |
| Official Name | HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 [Source:MGI Symbol;Acc:MGI:1913495] |
| Ensembl ID | ENSMUSG00000063802 |
| Bio databases IDs | |
| Aliases | HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 |
| Synonyms | 1500019G21Rik, FES1, HSP70 binding, HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1, HSPA (Hsp70) binding protein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hspbp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- Nucleotide exchange factor Fes1
- enzyme inhibitor activity
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- azoospermia
- neurodegeneration
role in cell
- apoptosis
- phosphorylation in
- quantity
- degradation in
- number
- meiosis
- mono-ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- intracellular space
- granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hspbp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein ubiquitination
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- protein folding
Cellular Component
Where in the cell the gene product is active
- extracellular space
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin protein ligase binding
- enzyme inhibitor activity
- adenyl-nucleotide exchange factor activity