Cdc42ep5 Gene Summary [Mouse]
Predicted to enable small GTPase binding activity. Acts upstream of or within JNK cascade and Rho protein signal transduction. Located in cytoplasm and plasma membrane. Orthologous to human CDC42EP5 (CDC42 effector protein 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdc42ep5 |
| Official Name | CDC42 effector protein (Rho GTPase binding) 5 [Source:MGI Symbol;Acc:MGI:1929745] |
| Ensembl ID | ENSMUSG00000063838 |
| Bio databases IDs | |
| Aliases | CDC42 effector protein (Rho GTPase binding) 5 |
| Synonyms | 1700027J19Rik, 2010007O02Rik, Borg3, CDC42 effector protein 5, CEP5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cdc42ep5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- BORG specific domain
- Bcl-2 homology 3 domain
- enzyme binding
- protein binding
- basic domain
- proline rich domain
Pathways
Biological processes and signaling networks where the Cdc42ep5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
phenotypes
- abnormal coat/hair pigmentation
role in cell
- migration
- formation
- disruption
- invasion by
- disruption in
- morphology
- polymerization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- cytosol
- filopodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cdc42ep5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- positive regulation of pseudopodium assembly
- positive regulation of actin filament polymerization
- JNK cascade
- Rho protein signal transduction
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- cytoplasm
- membrane
- cytosol
- endomembrane system
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- small GTPase binding