Hspa1b Gene Summary [Mouse]
Enables protein folding chaperone. Involved in protein folding. Acts upstream of or within binding activity of sperm to zona pellucida; negative regulation of apoptotic process; and response to heat. Located in cell body and mitochondrion. Part of zona pellucida receptor complex. Is expressed in several structures, including early conceptus; heart; humerus; and lung. Human ortholog(s) of this gene implicated in several diseases, including brain ischemia; obesity; toxic shock syndrome; type 2 diabetes mellitus; and urinary tract infection. Orthologous to human HSPA1B (heat shock protein family A (Hsp70) member 1B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hspa1b |
| Official Name | heat shock protein 1B [Source:MGI Symbol;Acc:MGI:99517] |
| Ensembl ID | ENSMUSG00000090877 |
| Bio databases IDs | |
| Aliases | heat shock protein 1B |
| Synonyms | heat shock protein 1B, hsp68, Hsp70, Hsp70-1, Hsp70.1, HSP70B1 |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hspa1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- protease binding
- MreB/Mbl protein
- NF-kappaB binding
- heat shock protein binding
- G-protein-coupled receptor binding
- ATP binding
- enzyme binding
- histone deacetylase binding
- protein domain specific binding
- enzyme
- protein binding
- receptor binding
- ATPase
- Fe-S protein assembly chaperone HscA
- chaperone protein DnaK
- Hsp70 protein
- ASKHA_ATPase-like
Pathways
Biological processes and signaling networks where the Hspa1b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ischemic injury
- tremor
- Huntington disease
- multiple system atrophy
role in cell
- activation in
- apoptosis
- formation
- killing
- binding
- fusion
- transformation
- survival
- size
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- aggresome
- intracellular space
- perinuclear region
- Nucleus
- centrosome
- centriole
- Mitochondria
- cytosol
- apical membrane
- basolateral membrane
- mitochondrial matrix
- mitochondrial outer membrane
- nuclear speckles
- membrane rafts
- perikaryon