Mirlet7a-1 Gene Summary [Mouse]
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Details
| Type | Micro RNA |
| Official Symbol | Mirlet7a-1 |
| Official Name | microRNA let7a-1 [Source:MGI Symbol;Acc:MGI:2676793] |
| Ensembl ID | ENSMUSG00000065421 |
| Bio databases IDs | |
| Aliases | microRNA let7a-1 |
| Synonyms | HSA-LET-7A, hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7a MM1, hsa-let-7b, HSA-LET-7C, hsa-let-7d, hsa-let-7e, hsa-let-7f, hsa-let-7f-1, hsa-let-7f-2, hsa-let-7g, hsa-let-7i, HSA-LET-7IN, hsa-miR-98, LET-7A, LET-7A-1, LET7A2, LET7A3, let-7a/f, LET-7B, LET7C, let-7c-1, let-7c-2, LET7D, LET-7D-opposite, LET7E, LET7F, LET7F1, LET-7F-2, LET7G, LET7I, let-7i-star, microRNA 3596b, microRNA 98, microRNA let7a, microRNA let-7a-1, microRNA LET7A2, microRNA let-7a-3, microRNA LET7af, microRNA let-7b, microRNA let-7c, microRNA let-7c-1, microRNA let7c-2, microRNA let-7d, microRNA let-7e, microRNA let-7f-1, microRNA let7f-1, opposite strand, microRNA let-7f-2, microRNA let-7g, microRNA let-7i, Mir3596b, Mir3596d, MIR98, MIRLET7A, MIRLET7A1, Mirlet7a-1-201, MIRLET7A2, Mirlet7a-2-201, MIRLET7A3, MIRLET7af, MIRLET7B, Mirlet7b-201, MIRLET7C, Mirlet7c-1, Mirlet7c-1-201, Mirlet7c-2, Mirlet7c-2-201, MIRLET7D, Mirlet7d-201, MIRLET7E, Mirlet7e-201, MIRLET7F, MIRLET7F1, Mirlet7f-1-201, Mirlet7f-1os, MIRLET7F2, Mirlet7f-2-201, MIRLET7G, Mirlet7g-201, MIRLET7I, Mirlet7i-201, MIRLET7L, MIRN98, MIRNLET-7, Mirnlet7a, MIRNLET7A1, MIRNLET7A1-5P, MIRNLET7A2, MIRNLET7A3, MIRNLET7B, MIRNLET7C, Mirnlet7c-1, Mirnlet7c-2, MIRNLET7D, MIRNLET7E, Mirnlet7f, MIRNLET7F1, MIRNLET7F2, MIRNLET7G, MIRNLET7I, mmu-Let-7, mmu-let-7a, mmu-let-7a-1, mmu-let-7a-2, mmu-let-7b, mmu-let-7c, mmu-let-7c-1, mmu-let-7c-2, mmu-let-7d, mmu-let-7e, mmu-let-7f, mmu-let-7f-1, mmu-let-7f-2, mmu-let-7g, mmu-let-7i, mmu-mir-7i, mmu-miR-98, mmu-pre-let-7, pre-let7a-1, pre-let-7g, pri-let-7a1, pri-let-7a-2, pri-let-7c, rno-let-7a, rno-let-7a-1, rno-let-7a-2, rno-let-7b, rno-let-7c, rno-let-7c-1, rno-let-7c-2, rno-let-7d, rno-let-7e, rno-let-7f, rno-let-7f-1, rno-let-7f-2, rno-let-7g, Rno-let-7i, rno-mir-3596b, rno-mir-3596d, rno-miR-98 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mirlet7a-1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mRNA 3' UTR binding
- mRNA binding
- translation repressor
- protein binding
- microRNA
Pathways
Biological processes and signaling networks where the Mirlet7a-1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- adenoma formation
- osteoarthritis
- tumorigenesis
- Alzheimer disease
- colorectal cancer
- metastasis
- experimental autoimmune encephalomyelitis
- kainic acid-induced epileptic seizure
role in cell
- phosphorylation in
- expression in
- number
- loss
- proliferation
- production in
- induction in
- apoptosis
- damage in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mirlet7a-1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of translation involved in gene silencing by miRNA
- gene silencing by miRNA
- negative regulation of interleukin-10 production
- negative regulation of cell proliferation
- negative regulation of interleukin-1 beta production
- negative regulation of cytokine production involved in inflammatory response
- regulation of cytokine production involved in inflammatory response
- positive regulation of neuron apoptotic process
- negative regulation of osteoblast differentiation
- negative regulation of BMP signaling pathway
- negative regulation of interleukin-6 production
- negative regulation of gene expression
- negative regulation of cholesterol biosynthetic process
- negative regulation of interleukin-8 production
- negative regulation of extracellular matrix disassembly
- negative regulation of interleukin-6-mediated signaling pathway
- mRNA cleavage involved in gene silencing by miRNA
- negative regulation of cytokine production
- negative regulation of tumor necrosis factor production
- negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- RNA-induced silencing complex
Molecular Function
What the gene product does at the molecular level
- mRNA 3'-UTR binding