Ilf2 Gene Summary [Mouse]
Predicted to enable DNA binding activity and double-stranded RNA binding activity. Predicted to be involved in positive regulation of DNA-templated transcription. Located in nucleolus. Is expressed in several structures, including brain; early conceptus; ganglia; gonad; and incisor. Orthologous to human ILF2 (interleukin enhancer binding factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Ilf2 |
| Official Name | interleukin enhancer binding factor 2 [Source:MGI Symbol;Acc:MGI:1915031] |
| Ensembl ID | ENSMUSG00000001016 |
| Bio databases IDs | |
| Aliases | interleukin enhancer binding factor 2 |
| Synonyms | 6230405A16Rik, Ab1-143, interleukin enhancer binding factor 2, NF45, NF-AT NF45, PRO3063, TEG-267, Tex261, TEX267 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ilf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DZF domain
- transcription regulator
- double-stranded RNA binding
- protein binding
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colon cancer
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- organismal death
- prostatic adenocarcinoma
- prostate cancer
- plasma cell myeloma
role in cell
- growth
- binding in
- phosphorylation in
- expression in
- transactivation in
- accumulation
- proliferation
- formation in
- transcription in
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- secretory granule lumen
- ficolin-1-rich granule lumen
- Cytoplasm
- Extracellular Space
- organelle lumens
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ilf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- nucleus
- specific granule lumen
- membrane
- cytosol
- nucleolus
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- RNA binding
- double-stranded RNA binding