Lin28a Gene Summary [Mouse]
Enables RNA binding activity and translation initiation factor binding activity. Involved in several processes, including cellular response to glucose stimulus; miRNA catabolic process; and positive regulation of intracellular signal transduction. Acts upstream of or within several processes, including miRNA metabolic process; negative regulation of glial cell differentiation; and regulation of gene expression. Located in nucleolus and rough endoplasmic reticulum. Is expressed in several structures, including early conceptus; embryo ectoderm; limb primordium; reproductive system; and tooth. Used to study nephroblastoma. Orthologous to human LIN28A (lin-28 homolog A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lin28a |
| Official Name | lin-28 homolog A (C. elegans) [Source:MGI Symbol;Acc:MGI:1890546] |
| Ensembl ID | ENSMUSG00000050966 |
| Bio databases IDs | |
| Aliases | lin-28 homolog A (C. elegans) |
| Synonyms | CSDD1, Gm10299, LIN-28, lin-28 homolog A, RGD1566408, Tex17, ZCCHC1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lin28a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- S1_like
- mRNA binding
- protein binding activity, bridging
- protein binding
- zinc finger domain
- Cold shock protein domain
- RNA binding
Pathways
Biological processes and signaling networks where the Lin28a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- tumorigenesis
- epithelial neoplasia
- growth failure
- mammary neoplasm
- breast cancer
- colorectal cancer
- epithelial cancer
- metastasis
- cancer
role in cell
- proliferation
- expression in
- survival
- growth
- regeneration
- accumulation in
- processing in
- differentiation
- activation in
- generation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- periendoplasmic reticulum area
- cytoplasmic mRNA processing body
- Nucleus
- polysomes
- cytosol
- nucleoli
- rough endoplasmatic reticulum
- stress granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lin28a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- germ cell development
- stem cell maintenance
- pre-miRNA processing
- positive regulation of neuron differentiation
- negative regulation of glial cell differentiation
- RNA 3' uridylation
- stem cell differentiation
- positive regulation of cytoplasmic translation
- cellular response to glucose stimulus
- RNA 3'-end processing
- negative regulation of pre-miRNA processing
- negative regulation of translation
- positive regulation of TOR signaling cascade
- positive regulation of protein kinase B signaling cascade
- miRNA catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasmic stress granule
- cytoplasm
- rough endoplasmic reticulum
- cytoplasmic mRNA processing body
- cytosol
- nucleolus
Molecular Function
What the gene product does at the molecular level
- miRNA binding
- zinc ion binding
- protein binding
- RNA binding
- mRNA binding
- G-quadruplex RNA binding
- pre-miRNA binding
- translation initiation factor binding