Tacc1 Gene Summary [Mouse]
Enables nuclear receptor binding activity; peroxisome proliferator activated receptor binding activity; and protein domain specific binding activity. Acts upstream of or within microtubule cytoskeleton organization; nervous system development; and regulation of microtubule-based process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; branchial arch; cardiovascular system; central nervous system; and respiratory system. Orthologous to human TACC1 (transforming acidic coiled-coil containing protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tacc1 |
| Official Name | transforming, acidic coiled-coil containing protein 1 [Source:MGI Symbol;Acc:MGI:2443510] |
| Ensembl ID | ENSMUSG00000065954 |
| Bio databases IDs | |
| Aliases | transforming, acidic coiled-coil containing protein 1 |
| Synonyms | 4833447E04Rik, AA960202, B230378H13RIK, Ga55, Tacc1a, transforming acidic coiled-coil containing protein 1, transforming, acidic coiled-coil containing protein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tacc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- ligand-dependent nuclear receptor interactor
- transcription co-activator
- PspA/IM30 family
- retinoic acid receptor binding
- protein domain specific binding
- estrogen receptor binding
- protein binding
- thyroid hormone receptor binding
- Bin/Amphiphysin/Rvs domain
- peroxisome proliferator activated receptor binding
- Transforming acidic coiled-coil-containing protein (TACC), C-terminal
- Family with sequence similarity 184, A and B
- Growth-arrest specific micro-tubule binding
- retinoid X receptor binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- COVID-19
- prostatic carcinoma
- prostate cancer
- diabetic nephropathy
- preeclampsia
- polycystic ovary syndrome
regulates
- ERK
- agar
role in cell
- apoptosis
- cell death
- proliferation
- growth
- organization
- transformation
- cell focus formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- centrosome
- cytosol
- nucleoplasm
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tacc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- cell proliferation
- positive regulation of transcription, DNA-dependent
- mitotic spindle organization
- microtubule cytoskeleton organization
- cerebral cortex development
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- membrane
- cytosol
- midbody
Molecular Function
What the gene product does at the molecular level
- ligand-dependent nuclear receptor binding
- protein binding
- ligand-dependent nuclear receptor transcription coactivator activity
- estrogen receptor binding
- retinoic acid receptor binding
- retinoid X receptor binding
- glucocorticoid receptor binding
- thyroid hormone receptor binding
- peroxisome proliferator activated receptor binding