TACC1 Gene Summary [Human]
This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]
Details
| Type | Protein Coding |
| Official Symbol | TACC1 |
| Official Name | transforming acidic coiled-coil containing protein 1 [Source:HGNC Symbol;Acc:HGNC:11522] |
| Ensembl ID | ENSG00000147526 |
| Bio databases IDs | |
| Aliases | transforming acidic coiled-coil containing protein 1 |
| Synonyms | 4833447E04Rik, AA960202, B230378H13RIK, Ga55, Tacc1a, transforming acidic coiled-coil containing protein 1, transforming, acidic coiled-coil containing protein 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TACC1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- ligand-dependent nuclear receptor interactor
- transcription co-activator
- PspA/IM30 family
- retinoic acid receptor binding
- protein domain specific binding
- estrogen receptor binding
- protein binding
- thyroid hormone receptor binding
- Bin/Amphiphysin/Rvs domain
- peroxisome proliferator activated receptor binding
- Transforming acidic coiled-coil-containing protein (TACC), C-terminal
- Family with sequence similarity 184, A and B
- Growth-arrest specific micro-tubule binding
- retinoid X receptor binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- COVID-19
- prostatic carcinoma
- prostate cancer
- diabetic nephropathy
- preeclampsia
- polycystic ovary syndrome
regulates
- ERK
- agar
role in cell
- apoptosis
- cell death
- proliferation
- growth
- organization
- transformation
- cell focus formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- centrosome
- cytosol
- nucleoplasm
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TACC1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- cell proliferation
- positive regulation of transcription, DNA-dependent
- mitotic spindle organization
- microtubule cytoskeleton organization
- cerebral cortex development
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- membrane
- cytosol
- midbody
Molecular Function
What the gene product does at the molecular level
- ligand-dependent nuclear receptor binding
- protein binding
- ligand-dependent nuclear receptor transcription coactivator activity
- estrogen receptor binding
- retinoic acid receptor binding
- retinoid X receptor binding
- glucocorticoid receptor binding
- thyroid hormone receptor binding
- peroxisome proliferator activated receptor binding