Aurkc Gene Summary [Mouse]
Enables protein kinase activity. Acts upstream of or within protein autophosphorylation. Located in chromosome, centromeric region and meiotic spindle midzone. Is expressed in brain; gonad; heart; liver; and metanephros. Human ortholog(s) of this gene implicated in spermatogenic failure 5. Orthologous to human AURKC (aurora kinase C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aurkc |
| Official Name | aurora kinase C [Source:MGI Symbol;Acc:MGI:1321119] |
| Ensembl ID | ENSMUSG00000070837 |
| Bio databases IDs | |
| Aliases | aurora kinase C |
| Synonyms | AIE1, AIE2, AIK3, ARK-3, AurC, aurora-C, aurora kinase C, HEL-S-90, IAK3, LOC100910268, LOC103691033, SPGF5, STK13 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Aurkc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- protein threonine/tyrosine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- ATP-binding domain
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Aurkc gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- infertility associated with multi-tailed spermatozoa and excessive DNA
role in cell
- attachment
- binding in
- formation
- binding
- serine phosphorylation in
- segregation
- colony formation by
- cytokinesis in
- cytokinesis
- segregation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- midbody center
- spindle apparatus
- centrosome
- midbody
- postmitotic bridges
- chromosome
- spindle pole
- central spindle
- centromeres
- chromosomal arms
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Aurkc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- meiotic cell cycle
- spindle midzone assembly involved in mitosis
- mitotic spindle organization
- attachment of spindle microtubules to kinetochore
- regulation of cytokinesis
- protein phosphorylation
- positive regulation of cytokinesis
Cellular Component
Where in the cell the gene product is active
- condensed chromosome
- spindle microtubule
- nucleus
- spindle pole centrosome
- spindle midzone
- cytoplasm
- spindle
- chromosome passenger complex
- kinetochore
- midbody
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein serine/threonine/tyrosine kinase activity
- protein kinase activity
- protein serine/threonine kinase activity