Csf1r Gene Summary [Mouse]
Enables several functions, including macrophage colony-stimulating factor receptor activity; protein homodimerization activity; and protein phosphatase binding activity. Involved in several processes, including nervous system development; positive regulation of intracellular signal transduction; and protein phosphorylation. Located in cell surface and plasma membrane. Part of CSF1-CSF1R complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and limb. Human ortholog(s) of this gene implicated in adult-onset leukoencephalopathy with axonal spheroids and pigmented glia; diabetes mellitus; gastrointestinal system cancer (multiple); lung cancer (multiple); and renal cell carcinoma. Orthologous to human CSF1R (colony stimulating factor 1 receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Csf1r |
| Official Name | colony stimulating factor 1 receptor [Source:MGI Symbol;Acc:MGI:1339758] |
| Ensembl ID | ENSMUSG00000024621 |
| Bio databases IDs | |
| Aliases | colony stimulating factor 1 receptor |
| Synonyms | BANDDOS, CD115, C-FMS, colony stimulating factor 1 receptor, CSF1 receptor, Csfmr, CSFR, FIM2, FMS, GPSC, HDLS, HDLS1, Mcsf1r, M-CSF-R, MCSF receptor, mrfms, receptor FOR CSF1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Csf1r often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PI3K binding domain
- Src binding domain
- STAT1 binding domain
- cytokine binding
- Mona binding domain
- Protein kinase domain
- protein-tyrosine kinase
- kinase insertion domain
- Grb2 binding domain
- docking domain
- p55 binding domain
- cytoplasmic domain
- ligand-binding domain
- Immunoglobulin like
- immunoglobulin-like protein domain
- membrane-proximal domain
- Tyrosine kinase, catalytic domain
- Immunoglobulin V-set domain
- transmembrane receptor
- p120rasgap binding domain
- extracellular domain
- Protein kinase (unclassified specificity)
- dimerization domain
- Protein tyrosine and serine/threonine kinase
- catalytic domain
- ectodomain
- immunoglobulin domain
- protein phosphatase binding
- Immunoglobulin I-set domain
- autophosphorylation site
- protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- macrophage colony stimulating factor receptor
- Protein Kinases, catalytic domain
- transmembrane receptor protein tyrosine kinase
- transmembrane domain
- protein homodimerization
- cytosolic tail domain
Pathways
Biological processes and signaling networks where the Csf1r gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pulmonary hypertensive arterial disease
- systemic sclerosis
- interstitial lung disease
- cancer
- epithelial neoplasia
- epithelial cancer
- liver cancer
- abdominal cancer
- leukemia
- neoplasia
role in cell
- quantity
- expression in
- apoptosis
- phosphorylation in
- function
- proliferation
- migration
- recruitment
- growth
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- Cytoplasm
- cell surface
- perinuclear region
- cellular membrane
- Nucleus
- Golgi Apparatus
- cytosol
- nucleoplasm
- nucleoli
- membrane processes
- perikaryon
- dendrites
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Csf1r gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- regulation of cell shape
- peptidyl-tyrosine phosphorylation
- regulation of MAPK cascade
- forebrain neuron differentiation
- multicellular organismal development
- hemopoiesis
- positive regulation of protein tyrosine kinase activity
- negative regulation of cell proliferation
- positive regulation of cell proliferation
- mammary gland duct morphogenesis
- protein autophosphorylation
- axon guidance
- regulation of bone resorption
- positive regulation of tyrosine phosphorylation of STAT protein
- olfactory bulb development
- inflammatory response
- response to ischemia
- cytokine-mediated signaling pathway
- positive regulation of macrophage chemotaxis
- positive regulation of kinase activity
- monocyte differentiation
- positive regulation of chemokine production
- cellular response to macrophage colony-stimulating factor stimulus
- macrophage differentiation
- signal transduction
- macrophage colony-stimulating factor signaling pathway
- transmembrane receptor protein tyrosine kinase signaling pathway
- cell-cell junction maintenance
- osteoclast differentiation
- regulation of actin cytoskeleton organization
- negative regulation of apoptotic process
- innate immune response
- ruffle organization
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of protein phosphorylation
- cellular response to cytokine stimulus
- positive regulation of protein kinase B signaling cascade
- positive regulation of cell motility
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- receptor complex
- plasma membrane
- nucleoplasm
- cell surface
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein tyrosine kinase activity
- growth factor binding
- protein homodimerization activity
- protein phosphatase binding
- protein binding
- macrophage colony-stimulating factor receptor activity
- cytokine binding