Oprd1 Gene Summary [Mouse]
Enables G protein-coupled opioid receptor activity. Acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; adult locomotory behavior; and neuropeptide signaling pathway. Located in membrane. Is active in neuronal dense core vesicle. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut; and neural retina. Human ortholog(s) of this gene implicated in alcohol dependence; alcohol use disorder; drug dependence (multiple); opioid abuse; and withdrawal disorder. Orthologous to human OPRD1 (opioid receptor delta 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Oprd1 |
| Official Name | opioid receptor, delta 1 [Source:MGI Symbol;Acc:MGI:97438] |
| Ensembl ID | ENSMUSG00000050511 |
| Bio databases IDs | |
| Aliases | opioid receptor, delta 1 |
| Synonyms | delta opioid receptor, deltaOR, DOP, DOR, DOR-1, mDOR, Nbor, OPIATE delta receptor, OPIATE δ receptor, OPIOID receptor delta, opioid receptor delta 1, opioid receptor, delta 1, OPIOID receptor δ, opioid receptor δ 1, opioid receptor, δ 1, OPRD, δ Opiate Receptor, δ Opioid Receptor, δ OR |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Oprd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- G-protein coupled peptide receptor
- opioid receptor
- GRK2 phosphorylation site
- intracellular loop
- Cholecystokinin A receptor, N-terminal
- lumenal/extracellular domain
- protein binding
- receptor binding
- seven-transmembrane G protein-coupled receptor superfamily
- ligand-induced binding site
- cytoplasmic domain
- transmembrane domain
- 7 transmembrane receptor (rhodopsin family)
- tail domain
- cytosolic tail domain
- distal tail domain
Pathways
Biological processes and signaling networks where the Oprd1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- HIV infection
- hepatitis C
- cancer
- acquired immunodeficiency syndrome
- depressive disorder
- cirrhosis
- postoperative pain
- head and neck cancer
- metastasis
- infection
role in cell
- expression in
- production in
- binding in
- chemotaxis
- outgrowth
- exocytosis
- release
- response by
- internalization by
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- synaptic vesicle membrane
- organelle
- Cytoplasm
- cell surface
- intracellular space
- cellular membrane
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- presynaptic membrane
- postsynaptic membrane
- synaptic membrane
- perinuclear space
- dendritic spines
- nerve ending
- dense-core vesicles
- cytoplasmic vesicles
- smooth endoplasmatic reticulum
- rough endoplasmatic reticulum
- secretory granules
- perikaryon
- axons
- dendrites
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Oprd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- opioid receptor signaling pathway
- G-protein coupled receptor signaling pathway
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- adult locomotory behavior
- response to nicotine
- phospholipase C-activating G-protein coupled receptor signaling pathway
- eating behavior
- negative regulation of gene expression
- neuropeptide signaling pathway
- immune response
- regulation of mitochondrial membrane potential
- cellular response to growth factor stimulus
- cellular response to toxin
- negative regulation of protein complex assembly
- positive regulation of CREB transcription factor activity
- cellular response to hypoxia
- regulation of calcium ion transport
- positive regulation of peptidyl-serine phosphorylation
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- dendrite membrane
- synaptic vesicle membrane
- neuron projection
- plasma membrane
- axon terminus
Molecular Function
What the gene product does at the molecular level
- opioid receptor activity
- neuropeptide binding
- protein binding
- enkephalin receptor activity
- receptor serine/threonine kinase binding