Gpr12 Gene Summary [Mouse]
Enables phosphatidylcholine binding activity. Acts upstream of or within G protein-coupled receptor signaling pathway and intracellular calcium ion homeostasis. Predicted to be active in cytoplasm and plasma membrane. Is expressed in central nervous system; gut; and liver. Used to study obesity. Orthologous to human GPR12 (G protein-coupled receptor 12). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Gpr12 |
| Official Name | G-protein coupled receptor 12 [Source:MGI Symbol;Acc:MGI:101909] |
| Ensembl ID | ENSMUSG00000041468 |
| Bio databases IDs | |
| Aliases | G-protein coupled receptor 12 |
| Synonyms | Gpcr01, GPCR12, Gpcr20, GPCR21, G protein-coupled receptor 12, LOC283535, PPP1R84 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gpr12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- phospholipid binding
- binding protein
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Gpr12 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight gain
- obesity
regulates
- D-glucose
- Ca2+
- cyclic AMP
- triacylglycerol
- cholesterol
- HDL/cholesterol
- LDL/cholesterol
- RHOA
role in cell
- proliferation
- differentiation
- outgrowth
- homeostasis in
- extension
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- perinuclear space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gpr12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- regulation of metabolic process
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- cellular calcium ion homeostasis
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- phosphatidylcholine binding