MYOZ1 Gene Summary [Human]
The protein encoded by this gene is primarily expressed in the skeletal muscle, and belongs to the myozenin family. Members of this family function as calcineurin-interacting proteins that help tether calcineurin to the sarcomere of cardiac and skeletal muscle. They play an important role in modulation of calcineurin signaling. [provided by RefSeq, Apr 2012]
Details
| Type | Protein Coding |
| Official Symbol | MYOZ1 |
| Official Name | myozenin 1 [Source:HGNC Symbol;Acc:HGNC:13752] |
| Ensembl ID | ENSG00000177791 |
| Bio databases IDs | |
| Aliases | myozenin 1, calsarcin-2 |
| Synonyms | 2310001N11Rik, CS-2, FATZ, MYOZ, myozenin 1, RGD1561064 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MYOZ1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Calcineurin-binding protein (Calsarcin)
- cytoskeletal protein binding
- type 1 serine/threonine specific protein phosphatase inhibitor
- actinin binding
- protein binding activity, bridging
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- actin cytoskeleton
- Nucleus
- sarcomere
- I band
- Z line
- pseudopodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MYOZ1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of skeletal muscle tissue regeneration
- myofibril assembly
- negative regulation of transcription from RNA polymerase II promoter
- wound healing
- skeletal muscle tissue development
- negative regulation of calcineurin-NFAT signaling cascade
- sarcomere organization
- skeletal muscle fiber adaptation
Cellular Component
Where in the cell the gene product is active
- Z disc
- nucleus
- actin cytoskeleton
- pseudopodium
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase inhibitor activity
- protein binding
- actin binding
- actinin binding
- FATZ binding
- telethonin binding