Atp6v0d2 Gene Summary [Mouse]
Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in vacuolar acidification and vacuolar transport. Located in early endosome. Is expressed in several structures, including genitourinary system; limb; musculoskeletal system; respiratory system; and sensory organ. Orthologous to human ATP6V0D2 (ATPase H+ transporting V0 subunit d2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp6v0d2 |
| Official Name | ATPase, H+ transporting, lysosomal V0 subunit D2 [Source:MGI Symbol;Acc:MGI:1924415] |
| Ensembl ID | ENSMUSG00000028238 |
| Bio databases IDs | |
| Aliases | ATPase, H+ transporting, lysosomal V0 subunit D2 |
| Synonyms | 1620401A02Rik, ATP6D2, ATPase, H+ transporting, lysosomal V0 subunit D2, ATPase H+ transporting V0 subunit D2, Atpv6, H+-ATPase D2 subunit, V-ATPase, V-ATPase d2, VMA6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atp6v0d2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein of unknown function (DUF2764)
- ATP synthase (C/AC39) subunit
- protein binding
- transporter
Pathways
Biological processes and signaling networks where the Atp6v0d2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- tauopathy
- idiopathic scoliosis
- osteopetrosis
role in cell
- expression in
- production in
- apoptosis
- phosphorylation in
- differentiation
- depolarization
- escape
- abnormal morphology
- absorption in
- swelling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- endosomes
- apical membrane
- lysosome membrane
- endosomal membrane
- early endosomes
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atp6v0d2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of macroautophagy
- vacuolar transport
- vacuolar acidification
Cellular Component
Where in the cell the gene product is active
- early endosome
- plasma membrane proton-transporting V-type ATPase complex
- extracellular vesicular exosome
- vacuolar proton-transporting V-type ATPase complex
- membrane
- phagocytic vesicle membrane
- proton-transporting V-type ATPase, V0 domain
- endosome membrane
- apical plasma membrane
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- proton-transporting ATPase activity, rotational mechanism