Upk1b Gene Summary [Mouse]
Acts upstream of or within response to bacterium. Located in apical plasma membrane. Is active in apical plasma membrane urothelial plaque. Is expressed in genitourinary system; mesothelium; pharyngo-tympanic tube; pharynx epithelium; and skin. Orthologous to human UPK1B (uroplakin 1B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Upk1b |
| Official Name | uroplakin 1B [Source:MGI Symbol;Acc:MGI:98912] |
| Ensembl ID | ENSMUSG00000049436 |
| Bio databases IDs | |
| Aliases | uroplakin 1B |
| Synonyms | TSPAN20, UP1b, UPIB, UPK1, uroplakin 1B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Upk1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tetraspanin_LEL
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- apical membrane
- microsomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Upk1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
- response to bacterium
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural molecule activity