Incenp Gene Summary [Mouse]
Predicted to enable molecular function activator activity. Predicted to be involved in meiotic spindle midzone assembly; metaphase chromosome alignment; and mitotic cytokinesis. Located in several cellular components, including chromocenter; midbody; and synaptonemal complex. Is expressed in brain ventricular layer; cerebral cortex subventricular zone; and heart. Orthologous to human INCENP (inner centromere protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Incenp |
| Official Name | inner centromere protein [Source:MGI Symbol;Acc:MGI:1313288] |
| Ensembl ID | ENSMUSG00000024660 |
| Bio databases IDs | |
| Aliases | inner centromere protein |
| Synonyms | 2700067E22Rik, AU019509, C130081E20, inner centromere protein |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Incenp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Arginine and glutamate-rich 1
- MAP7 (E-MAP-115) family
- Inner centromere protein, ARK binding region
- Ezrin/radixin/moesin, alpha-helical domain
- Trichohyalin-plectin-homology domain
- protein binding
- Chromosome passenger complex (CPC) protein INCENP N terminal
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- epithelial cancer
- kidney carcinoma
- renal cancer
- renal clear cell adenocarcinoma
- renal clear cell cancer
- prostatic carcinoma
- epithelial basal cell carcinoma
- MYC mutation positive B-cell lymphoma
- lymphomagenesis
role in cell
- cell death
- phosphorylation in
- formation
- formation in
- mitosis
- number
- segregation
- serine phosphorylation in
- synthesis in
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- microtubule cytoskeleton
- spindle apparatus
- midbody
- cytosol
- chromosome
- nucleoplasm
- nuclear bodies
- nuclear scaffolds
- kinetochores
- centromeres
- synaptonemal complexes
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Incenp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spindle midzone assembly involved in meiosis
- metaphase plate congression
- spindle midzone assembly involved in mitosis
- positive regulation of mitotic cell cycle spindle assembly checkpoint
- cytokinesis after mitosis
- chromosome segregation
- mitotic cell cycle
- spindle assembly involved in mitosis
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- nuclear body
- central element
- lateral element
- kinetochore
- chromosome, centromeric region
- centromeric heterochromatin
- microtubule
- nucleoplasm
- nucleus
- spindle
- chromocenter
- cytosol
- macromolecular complex
- chromosome passenger complex
- midbody
Molecular Function
What the gene product does at the molecular level
- protein binding