AURKC Gene Summary [Human]
This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | AURKC |
| Official Name | aurora kinase C [Source:HGNC Symbol;Acc:HGNC:11391] |
| Ensembl ID | ENSG00000105146 |
| Bio databases IDs | |
| Aliases | aurora kinase C |
| Synonyms | AIE1, AIE2, AIK3, ARK-3, AurC, aurora-C, aurora kinase C, HEL-S-90, IAK3, LOC100910268, LOC103691033, SPGF5, STK13 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AURKC often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- protein threonine/tyrosine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- ATP-binding domain
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the AURKC gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- infertility associated with multi-tailed spermatozoa and excessive DNA
role in cell
- attachment
- binding in
- formation
- binding
- serine phosphorylation in
- segregation
- colony formation by
- cytokinesis in
- cytokinesis
- segregation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- midbody center
- spindle apparatus
- centrosome
- midbody
- postmitotic bridges
- chromosome
- spindle pole
- central spindle
- centromeres
- chromosomal arms
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AURKC gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- meiotic cell cycle
- spindle midzone assembly involved in mitosis
- mitotic spindle organization
- attachment of spindle microtubules to kinetochore
- regulation of cytokinesis
- protein phosphorylation
- positive regulation of cytokinesis
Cellular Component
Where in the cell the gene product is active
- condensed chromosome
- spindle microtubule
- nucleus
- spindle pole centrosome
- spindle midzone
- cytoplasm
- spindle
- chromosome passenger complex
- kinetochore
- midbody
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein serine/threonine/tyrosine kinase activity
- protein kinase activity
- protein serine/threonine kinase activity