Sphk1 Gene Summary [Mouse]
This gene encodes a kinase that phosphorylates sphingosine into sphingosine-1-phosphate, which is involved in cell differentiation, motility, and apoptosis. The encoded protein plays a role in maintaining cellular levels of sphingosine-1-phosphate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Details
| Type | Protein Coding |
| Official Symbol | Sphk1 |
| Official Name | sphingosine kinase 1 [Source:MGI Symbol;Acc:MGI:1316649] |
| Ensembl ID | ENSMUSG00000061878 |
| Bio databases IDs | |
| Aliases | sphingosine kinase 1 |
| Synonyms | 1110006G24Rik, SK1, Sphingosine kinase, sphingosine kinase 1, SPHK, Sphk1a, Spk1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sphk1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- traf2 binding domain
- bioactive lipid receptor
- lipid kinase
- lipid binding
- calmodulin binding
- catalytic domain
- ATP-binding domain
- protein phosphatase binding
- D-erythro-sphingosine kinase
- ATP binding
- protein binding
- magnesium ion binding
- DNA binding
- phosphorylation site
- Diacylglycerol kinase catalytic domain (presumed)
- kinase
- sphinganine kinase
- TRAF binding domain
- Diacylglycerol kinase catalytic domain
- acetyltransferase
Pathways
Biological processes and signaling networks where the Sphk1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- neoplasia
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- systemic lupus erythematosus
- rheumatoid arthritis
- medulloblastoma SHH subtype
role in cell
- apoptosis
- expression in
- cell death
- cell viability
- phosphorylation in
- activation
- differentiation
- molecular cleavage in
- proliferation
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent-insoluble fractions
- membrane fraction
- intracellular membrane-bounded organelle
- presynaptic regions
- cilia
- perinuclear region
- cellular membrane
- Nucleus
- Plasma Membrane
- endosomes
- lysosome
- cytosol
- endosomal membrane
- nucleoplasm
- synaptic vesicles
- neurites
- endocytotic vesicle
- clathrin-coated pits
- axons
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sphk1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- sphingosine biosynthetic process
- positive regulation of mitosis
- positive regulation of NF-kappaB transcription factor activity
- sphingosine-1-phosphate signaling pathway
- positive regulation of angiogenesis
- positive regulation of smooth muscle contraction
- positive regulation of cell growth
- inflammatory response
- blood vessel development
- positive regulation of fibroblast proliferation
- positive regulation of interleukin-17 production
- positive regulation of protein ubiquitination
- DNA biosynthetic process
- cellular response to hydrogen peroxide
- regulation of endocytosis
- phosphorylation
- calcium-mediated signaling
- intracellular signal transduction
- sphingolipid biosynthetic process
- negative regulation of ceramide biosynthetic process
- sphingosine metabolic process
- protein acetylation
- sphingoid catabolic process
- brain development
- positive regulation of mitotic cell cycle
- positive regulation of p38MAPK cascade
- negative regulation of apoptotic process
- cellular response to growth factor stimulus
- regulation of tumor necrosis factor-mediated signaling pathway
- positive regulation of peptidyl-threonine phosphorylation
- regulation of interleukin-1 beta production
- cellular response to vascular endothelial growth factor stimulus
- regulation of phagocytosis
- response to tumor necrosis factor
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- endocytic vesicle
- nucleus
- cytoplasm
- coated pit
- intracellular membrane-bounded organelle
- membrane
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sphinganine kinase activity
- sphingosine-1-phosphate receptor activity
- acetyltransferase activity
- lipid binding
- magnesium ion binding
- ATP binding
- DNA binding
- calmodulin binding
- D-erythro-sphingosine kinase activity
- protein binding
- lipid kinase activity
- protein phosphatase 2A binding