L3mbtl3 Gene Summary [Mouse]
Predicted to enable several functions, including histone binding activity; identical protein binding activity; and methylation-dependent protein binding activity. Involved in regulation of ubiquitin-dependent protein catabolic process. Acts upstream of or within erythrocyte maturation; granulocyte differentiation; and macrophage differentiation. Located in nucleus. Is expressed in retina. Orthologous to human L3MBTL3 (L3MBTL histone methyl-lysine binding protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | L3mbtl3 |
| Official Name | L3MBTL3 histone methyl-lysine binding protein [Source:MGI Symbol;Acc:MGI:2143628] |
| Ensembl ID | ENSMUSG00000039089 |
| Bio databases IDs | |
| Aliases | L3MBTL3 histone methyl-lysine binding protein |
| Synonyms | AI481284, L3MBTL3 histone methyl-lysine binding protein, L3MBTL histone methyl-lysine binding protein 3, MBT-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse L3mbtl3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sterile alpha motif
- Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
- mbt repeat
- SAM (Sterile alpha motif )
- SAM domain (Sterile alpha motif)
- chromatin binding
- protein binding
- identical protein binding
- malignant brain tumor (MBT) repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- epithelial cancer
- chronic obstructive pulmonary disease
- prostate cancer
- hypertension
- non-insulin-dependent diabetes mellitus
- myocardial infarction
- chronic kidney disease
- alcoholic liver disease
- multiple sclerosis
role in cell
- quantity
- accumulation in
- differentiation
- accumulation
- ubiquitination in
- maturation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse L3mbtl3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
- negative regulation of transcription, DNA-dependent
- chromatin organization
- granulocyte differentiation
- regulation of methylation-dependent chromatin silencing
- erythrocyte maturation
- macrophage differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- zinc ion binding
- protein binding
- histone binding
- chromatin binding