C2cd6 Gene Summary [Mouse]
Involved in flagellated sperm motility; sperm capacitation; and vesicle-mediated transport to the plasma membrane. Acts upstream of or within calcium ion transmembrane transport; protein-containing complex assembly; and single fertilization. Located in sperm principal piece. Part of CatSper complex. Is active in sperm flagellum. Human ortholog(s) of this gene implicated in spermatogenic failure 68. Orthologous to human C2CD6 (C2 calcium dependent domain containing 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | C2cd6 |
| Official Name | C2 calcium dependent domain containing 6 [Source:MGI Symbol;Acc:MGI:1920713] |
| Ensembl ID | ENSMUSG00000072295 |
| Bio databases IDs | |
| Aliases | C2 calcium dependent domain containing 6 |
| Synonyms | 1700052H20Rik, 4930408G06Rik, ALS2CR11, Als2cr11b, C2 calcium dependent domain containing 6, C2cd6b, FLJ25351, Gm33589, LOC102552195, SPGF68 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse C2cd6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Amyotrophic lateral sclerosis 2 candidate 11
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- cancer
- epithelial basal cell carcinoma
- spermatogenic failure 68
- breast carcinoma
- non-melanoma skin cancer
- cocaine-related disorder
regulated by
regulates
- Ca2+
- protein-protein complex
role in cell
- abnormal morphology
- capacitation
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- sperm tail
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse C2cd6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sperm capacitation
- sperm motility
- spermatogenesis
Cellular Component
Where in the cell the gene product is active
- sperm principal piece
- CatSper complex
Molecular Function
What the gene product does at the molecular level
- protein binding