Nanos1 Gene Summary [Mouse]

This gene encodes a CCHC-type zinc finger protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2and may be involved in regulating translation as a post-transcriptional repressor. Mutations in a similar protein in human are associated with spermatogenic impairment. [provided by RefSeq, Sep 2015]

Details

Type
Protein Coding
Official Symbol
Nanos1
Official Name
nanos C2HC-type zinc finger 1 [Source:MGI Symbol;Acc:MGI:2669254]
Ensembl ID
ENSMUSG00000072437
Bio databases IDs NCBI: 332397 Ensembl: ENSMUSG00000072437
Aliases nanos C2HC-type zinc finger 1
Synonyms EC Rep1a, LOC340719, nanos C2HC-type zinc finger 1, NOS-1, SPGF12, ZC2HC12A
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nanos1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • translation repressor
  • protein binding
  • zinc finger domain
  • enzyme activator activity
  • Nanos RNA binding domain
  • translation regulator

Pathways

Biological processes and signaling networks where the Nanos1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • diabetes mellitus
  • spermatogenic failure 12
  • alcoholic pancreatitis
  • rotator cuff injury
  • lung adenocarcinoma
  • lung adenocarcinoma formation
regulated by
regulates
role in cell
  • growth
  • migration
  • invasion by
  • formation
  • maintenance
  • migration by
  • translation in
  • formation in
  • aggregation

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • perinuclear region

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Nanos1 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • tissue homeostasis
  • posttranscriptional regulation of gene expression
  • mRNA destabilization
  • regulation of cell growth
  • oogenesis
  • cell migration
  • negative regulation of translation
  • epithelial cell migration

Cellular Component

Where in the cell the gene product is active
  • perinuclear region of cytoplasm
  • cytoplasm

Molecular Function

What the gene product does at the molecular level
  • zinc ion binding
  • protein binding
  • translation repressor activity
  • mRNA binding
  • enzyme activator activity

Gene-Specific Assays for Results You Can Trust

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