Ctnnd1 Gene Summary [Mouse]
Enables cell-cell adhesion mediator activity; protein domain specific binding activity; and protein phosphatase binding activity. Involved in cell migration involved in sprouting angiogenesis and positive regulation of protein localization to cell-cell junction. Acts upstream of or within several processes, including glomerulus morphogenesis; positive regulation of protein metabolic process; and salivary gland development. Located in several cellular components, including apicolateral plasma membrane; bicellular tight junction; and lamellipodium. Part of flotillin complex. Is active in adherens junction. Is expressed in several structures, including 4-8 cell stage embryo; alimentary system; central nervous system; metanephros; and sensory organ. Human ortholog(s) of this gene implicated in blepharocheilodontic syndrome 2. Orthologous to human CTNND1 (catenin delta 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ctnnd1 |
| Official Name | catenin (cadherin associated protein), delta 1 [Source:MGI Symbol;Acc:MGI:105100] |
| Ensembl ID | ENSMUSG00000034101 |
| Bio databases IDs | |
| Aliases | catenin (cadherin associated protein), delta 1 |
| Synonyms | BCDS2, CAS, catenin delta 1, catenin δ 1, CATNS, CTND1, CTNND, CTNN delta1, CTNN δ1, mKIAA0384, P120, P120CAS, p120(CAS), p120-Catenin, P120CTN, p120(CTN), Pp120 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ctnnd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Armadillo/beta-catenin-like repeat
- protein kinase binding
- beta-catenin binding
- cell adhesion molecule binding
- protein phosphatase binding
- coiled-coil domain
- protein domain specific binding
- protein binding
- receptor binding
- head domain
- phosphatase inhibitor
- Armadillo/beta-catenin-like repeats
- cadherin binding
- Rho-binding domain
- armadillo repeat domain
- phosphatase binding
Pathways
Biological processes and signaling networks where the Ctnnd1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- epithelial cancer
- cancer
- metastasis
- uterine leiomyoma
- leiomyomatosis
- survival
- tumorigenesis
- androgenic alopecia
- squamous cell cancer of the oral cavity
role in cell
- expression in
- binding in
- apoptosis
- growth
- cell death
- differentiation
- proliferation
- inhibition in
- phosphorylation in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- membrane fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- apicolateral membrane
- actin halo
- glutaminergic synapse
- organelle
- Cytoplasm
- cell surface
- intracellular space
- membrane surface
- cellular membrane
- filamentous network
- Plasma Membrane
- basal bodies
- centrosome
- microtubules
- midbody
- intercellular junctions
- cell-cell contacts
- granules
- cytosol
- cytoplasmic face of plasma membrane
- membrane ruffles
- lateral plasma membrane
- spindle fibers
- dendritic spines
- growth cone
- synapse
- cytoplasmic vesicles
- anchoring junction
- tight junctions
- zonula adherens
- cleavage furrow
- dendrites
- cell-cell adherens junctions
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ctnnd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- cell-cell adhesion mediated by cadherin
- Wnt receptor signaling pathway
- protein stabilization
Cellular Component
Where in the cell the gene product is active
- plasma membrane
- cell surface
- growth cone
- nucleus
- adherens junction
- cell-cell junction
- extracellular vesicular exosome
- cytoplasm
- dendritic spine
- zonula adherens
- cytosol
- catenin complex
- midbody
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding
- cadherin binding
- beta-catenin binding
- receptor binding