Pum2 Gene Summary [Mouse]
Enables lncRNA binding activity and pumilio-response element binding activity. Involved in several processes, including adipose tissue development; hair follicle development; and respiratory electron transport chain. Acts upstream of or within post-transcriptional regulation of gene expression and stress granule assembly. Located in cytoplasmic stress granule. Is expressed in several structures, including adipose tissue; alimentary system; brain; genitourinary system; and immune system. Orthologous to human PUM2 (pumilio RNA binding family member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pum2 |
| Official Name | pumilio RNA-binding family member 2 [Source:MGI Symbol;Acc:MGI:1931751] |
| Ensembl ID | ENSMUSG00000020594 |
| Bio databases IDs | |
| Aliases | pumilio RNA-binding family member 2 |
| Synonyms | 5730503J23Rik, PUMH2, PUMILIO2, pumilio RNA-binding family member 2, PUML2, Pumm2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pum2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Pumilio-like repeats
- mRNA 3' UTR binding
- Pumilio-family RNA binding domain
- Pumilio-family RNA binding repeat
- protein binding
- RNA-binding domain
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- osteoarthritis
- colorectal cancer
- azoxymethane/dextran sodium sulfate induced colorectal cancer
role in cell
- expression in
- apoptosis
- proliferation
- growth
- colony formation
- assembly
- expansion
- segregation
- organization
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- perinuclear region
- postsynaptic region
- Nucleus
- cytosol
- nuclear envelope
- stress granule
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pum2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- stress granule assembly
- 3'-UTR-mediated mRNA destabilization
- production of miRNAs involved in gene silencing by miRNA
- respiratory electron transport chain
- regulation of mRNA stability
- positive regulation of RIG-I signaling pathway
- mitochondrion organization
- adipose tissue development
- regulation of gene silencing by miRNA
- posttranscriptional regulation of gene expression
- regulation of chromosome segregation
- regulation of translation
- skeletal system development
- hair follicle development
- positive regulation of sprouting of injured axon
- chromosome organization
- positive regulation of gene silencing by miRNA
Cellular Component
Where in the cell the gene product is active
- nuclear membrane
- perinuclear region of cytoplasm
- cytoplasmic stress granule
- cytoplasm
- cytosol
- neuronal cell body
Molecular Function
What the gene product does at the molecular level
- miRNA binding
- protein binding
- RNA binding
- mRNA 3'-UTR binding