Zdhhc13 Gene Summary [Mouse]
Enables magnesium ion transmembrane transporter activity and palmitoyltransferase activity. Predicted to be involved in magnesium ion transmembrane transport. Located in Golgi membrane and Golgi-associated vesicle membrane. Is expressed in several structures, including early conceptus; esophagus epithelium; genitourinary system; molar; and sensory organ. Used to study Huntington's disease. Orthologous to human ZDHHC13 (zinc finger DHHC-type palmitoyltransferase 13). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zdhhc13 |
| Official Name | zinc finger, DHHC domain containing 13 [Source:MGI Symbol;Acc:MGI:1919227] |
| Ensembl ID | ENSMUSG00000030471 |
| Bio databases IDs | |
| Aliases | zinc finger, DHHC domain containing 13 |
| Synonyms | 2410004E01Rik, C530010M18, DHHC13, HIP14L, HIP3RP, kojak, skc4, zinc finger, DHHC domain containing 13, zinc finger DHHC-type palmitoyltransferase 13 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zdhhc13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- palmitoyltransferase
- transcription regulator
- Ankyrin repeats (many copies)
- Ankyrin repeats (3 copies)
- DHHC palmitoyltransferase
- magnesium ion transporter
- protein binding
- Ankyrin repeat
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- lung adenocarcinoma formation
phenotypes
- abnormal Kupffer cell morphology
- abnormal cerebellum morphology
- abnormal cerebral cortex morphology
- abnormal corpus callosum morphology
- abnormal globus pallidus morphology
- abnormal hair cycle
- abnormal hair follicle morphology
- abnormal hair growth
- abnormal hair shaft morphology
- abnormal motor coordination/ balance
- abnormal motor learning
- abnormal renal glomerulus morphology
- abnormal trabecular bone morphology
- alopecia
- amyloidosis
- cachexia
- decreased body size
- decreased body weight
- decreased bone mineral density
- decreased brain weight
- decreased brown adipose tissue amount
- decreased hair follicle number
- decreased leukocyte cell number
- decreased neuron number
- decreased striatum size
- decreased white adipose tissue amount
- enlarged liver
- enlarged spleen
- epidermal hyperplasia
- hyperkeratosis
- hypoactivity
- increased blood urea nitrogen level
- increased circulating alanine transaminase level
- increased circulating aspartate transaminase level
- increased circulating bilirubin level
- increased circulating creatine kinase level
- increased neuron apoptosis
- increased neutrophil cell number
- kyphosis
- muscular atrophy
- osteoporosis
- premature death
- rough coat
- slow postnatal weight gain
- small thalamus
- sparse hair
- thick epidermis
- thin dermal layer
- wrinkled skin
role in cell
- palmitoylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zdhhc13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- protein palmitoylation
Cellular Component
Where in the cell the gene product is active
- membrane
- Golgi-associated vesicle membrane
- Golgi membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein-cysteine S-palmitoleyltransferase activity
- palmitoyltransferase activity
- magnesium ion transmembrane transporter activity