Nfxl1 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in brain. Orthologous to human NFXL1 (nuclear transcription factor, X-box binding like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nfxl1 |
| Official Name | nuclear transcription factor, X-box binding-like 1 [Source:MGI Symbol;Acc:MGI:1923646] |
| Ensembl ID | ENSMUSG00000072889 |
| Bio databases IDs | |
| Aliases | nuclear transcription factor, X-box binding-like 1 |
| Synonyms | 1700012H24Rik, AW538212, CDZFP, D430033A06Rik, DNABF, GCF, Gm1058, HOZFP, nuclear transcription factor, X-box binding-like 1, OZFP, RGD1359201, TCF9, URCC5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nfxl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nfxl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription, DNA-dependent
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- membrane
- chromatin
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity