Zdhhc6 Gene Summary [Mouse]
Predicted to enable protein-cysteine S-palmitoyltransferase activity and protein-cysteine S-stearoyltransferase activity. Involved in protein palmitoylation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Is expressed in several structures, including eye; genitourinary system; heart; lung epithelium; and trunk somite. Orthologous to human ZDHHC6 (zinc finger DHHC-type palmitoyltransferase 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Zdhhc6 |
| Official Name | zinc finger, DHHC domain containing 6 [Source:MGI Symbol;Acc:MGI:1914230] |
| Ensembl ID | ENSMUSG00000024982 |
| Bio databases IDs | |
| Aliases | zinc finger, DHHC domain containing 6 |
| Synonyms | 2400007G07Rik, 5930409M18Rik, DHHC-6, FLJ21952, zinc finger, DHHC domain containing 6, zinc finger DHHC-type palmitoyltransferase 6, ZNF376 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zdhhc6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein-cysteine S-acyltransferase
- palmitoyltransferase
- DHHC palmitoyltransferase
- enzyme
- protein binding
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- migraines
- lung adenocarcinoma
- lung adenocarcinoma formation
role in cell
- phosphorylation in
- binding in
- palmitoylation in
- folding in
- colony formation ability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cellular membrane
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zdhhc6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of mitochondrial fusion
- peptidyl-L-cysteine S-palmitoylation
- protein palmitoylation
- protein targeting to membrane
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- Golgi apparatus
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein-cysteine S-palmitoleyltransferase activity
- protein binding
- palmitoyltransferase activity