Plekhf1 Gene Summary [Mouse]
Predicted to enable phosphatidylinositol-3-phosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylinositol-5-phosphate binding activity. Predicted to be involved in several processes, including endosome organization; endosome to lysosome transport; and protein localization to plasma membrane. Predicted to be located in nucleus and perinuclear region of cytoplasm. Predicted to be active in early endosome and lysosome. Predicted to colocalize with endosome. Orthologous to human PLEKHF1 (pleckstrin homology and FYVE domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plekhf1 |
| Official Name | pleckstrin homology domain containing, family F (with FYVE domain) member 1 [Source:MGI Symbol;Acc:MGI:1919537] |
| Ensembl ID | ENSMUSG00000074170 |
| Bio databases IDs | |
| Aliases | pleckstrin homology domain containing, family F (with FYVE domain) member 1 |
| Synonyms | 1810013P09RIK, APPD, LAPF, PHAFIN1, pleckstrin homology and FYVE domain containing 1, pleckstrin homology domain containing, family F (with FYVE domain) member 1, ZFYVE15 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plekhf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FYVE domain like superfamily
- FYVE zinc finger
- Protein present in Fab1, YOTB, Vac1, and EEA1
- PH domain
- PHD finger superfamily
- protein binding
- Pleckstrin homology-like domain
- phosphatidylinositol binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- binding in
- endocytosis by
- apoptosis
- aggregation in
- organization
- endocytosis
- autophagy by
- tyrosine phosphorylation in
- lysosomal membrane permeabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endosomes
- lysosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plekhf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of autophagy
- vesicle organization
- endosome organization
- apoptotic process
- endosome to lysosome transport
- positive regulation of intrinsic apoptotic signaling pathway
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- nucleus
- early endosome
- endosome
- perinuclear region of cytoplasm
- endosome membrane
- lysosomal membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-4-phosphate binding
- protein binding
- metal ion binding
- phosphatidylinositol-5-phosphate binding
- phosphatidylinositol binding
- phosphatidylinositol-3-phosphate binding