E2f5 Gene Summary [Mouse]
Enables DNA-binding transcription factor activity. Acts upstream of or within animal organ morphogenesis and regulation of DNA-templated transcription. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; eye; and genitourinary system. Used to study hydrocephalus. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human E2F5 (E2F transcription factor 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | E2f5 |
| Official Name | E2F transcription factor 5 [Source:MGI Symbol;Acc:MGI:105091] |
| Ensembl ID | ENSMUSG00000027552 |
| Bio databases IDs | |
| Aliases | E2F transcription factor 5 |
| Synonyms | E2F transcription factor 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse E2f5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- dimerization domain
- DNA binding domain
- transcription activation domain
- E2F/DP family winged-helix DNA-binding domain
- protein binding
- Dimerization domain of E2F transcription factors
- sequence-specific DNA binding
- transcription factor activity
Pathways
Biological processes and signaling networks where the E2f5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Bladder Cancer Signaling
- Breast Cancer Regulation by Stathmin1
- Cell Cycle Regulation by BTG Family Proteins
- Chronic Myeloid Leukemia Signaling
- Cyclins and Cell Cycle Regulation
- DNA Methylation and Transcriptional Repression Signaling
- Estrogen-mediated S-phase Entry
- Glioblastoma Multiforme Signaling
- Glioma Signaling
- Molecular Mechanisms of Cancer
- Non-Small Cell Lung Cancer Signaling
- Ovarian Cancer Signaling
- Pancreatic Adenocarcinoma Signaling
- Prostate Cancer Signaling
- Role of BRCA1 in DNA Damage Response
- Role of CHK Proteins in Cell Cycle Checkpoint Control
- Small Cell Lung Cancer Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- liver cancer
- hepatocellular carcinoma
- epithelial cancer
- Down syndrome
- ataxia
- hydrocephalus
- communicating hydrocephalus
- intraventricular hemorrhage
- congenital hydrocephalus
role in cell
- proliferation
- migration
- expression in
- growth
- S phase
- cell cycle progression
- colony formation
- invasion by
- invasiveness
- induction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- fibrillar center
- intracellular membrane-bounded organelle
- Cytoplasm
- sarcoplasm
- nucleoplasm
- nucleoli
- nuclear envelope
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse E2f5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- cell projection organization
- regulation of transcription from RNA polymerase II promoter
- organ morphogenesis
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- intracellular membrane-bounded organelle
- nucleolus
- chromatin
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- protein dimerization activity
- sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity