Tfdp1 Gene Summary [Mouse]
Enables DNA-binding transcription factor activity and cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of fat cell proliferation. Acts upstream of or within anoikis; epidermis development; and regulation of nucleobase-containing compound metabolic process. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and retina. Human ortholog(s) of this gene implicated in mismatch repair cancer syndrome. Orthologous to several human genes including TFDP1 (transcription factor Dp-1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tfdp1 |
| Official Name | transcription factor Dp 1 [Source:MGI Symbol;Acc:MGI:101934] |
| Ensembl ID | ENSMUSG00000038482 |
| Bio databases IDs | |
| Aliases | transcription factor Dp 1 |
| Synonyms | DILC, DP-1, DRTF1, TB2/DP1, transcription factor Dp-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tfdp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- DP-conserved box domain
- transcription regulator
- dimerization domain
- Dimerization domain of DP
- DNA binding domain
- nucleic acid binding
- transcription factor binding
- protein domain specific binding
- protein binding
- sequence-specific DNA binding
- DEF box
- phosphorylation site
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- E2F protein-binding domain
- double-stranded DNA binding
- E2F/DP family winged-helix DNA-binding domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the Tfdp1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Aryl Hydrocarbon Receptor Signaling
- Bladder Cancer Signaling
- Chronic Myeloid Leukemia Signaling
- Cyclins and Cell Cycle Regulation
- Estrogen-mediated S-phase Entry
- Glioma Signaling
- Molecular Mechanisms of Cancer
- Non-Small Cell Lung Cancer Signaling
- Ovarian Cancer Signaling
- Pancreatic Adenocarcinoma Signaling
- Prostate Cancer Signaling
- Small Cell Lung Cancer Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- osteogenesis imperfecta type III
- exencephaly
- colorectal cancer
- hereditary gingival fibromatosis
- growth failure
- Waldenström macroglobulinemia
role in cell
- proliferation
- cell death
- expression in
- growth
- G1 phase
- quantity
- G1/S phase transition
- apoptosis
- number
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tfdp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of G1/S transition of mitotic cell cycle
- epidermis development
- regulation of DNA biosynthetic process
- regulation of transcription, DNA-dependent
- transcription from RNA polymerase II promoter
- anoikis
- negative regulation of fat cell proliferation
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of sequence-specific DNA binding transcription factor activity
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- Rb-E2F complex
- cytoplasm
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein domain specific binding
- protein binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity