Gas2l3 Gene Summary [Mouse]
Predicted to enable actin filament binding activity and microtubule binding activity. Acts upstream of or within response to bacterium. Predicted to be located in actin cytoskeleton and microtubule cytoskeleton. Is expressed in heart. Orthologous to human GAS2L3 (growth arrest specific 2 like 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gas2l3 |
| Official Name | growth arrest-specific 2 like 3 [Source:MGI Symbol;Acc:MGI:1918780] |
| Ensembl ID | ENSMUSG00000074802 |
| Bio databases IDs | |
| Aliases | growth arrest-specific 2 like 3 |
| Synonyms | 8430435B07Rik, G2L3, Gm240, growth arrest-specific 2 like 3, LOC687775 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gas2l3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- Calponin homology domain
- actin binding
- calponin homology (CH) domain superfamily
- protein binding
- Growth-Arrest-Specific Protein 2 Domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dilated cardiomyopathy
- renal clear cell adenocarcinoma
- renal clear cell cancer
- cardiac fibrosis
role in cell
- proliferation
- number
- hypertrophy
- abnormal morphology
- abscission
- binucleation
- organization
- cytokinesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- microtubule cytoskeleton
- constriction sites
- actin cytoskeleton
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gas2l3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- actin crosslink formation
- microtubule cytoskeleton organization
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- cytoplasm
- actin cytoskeleton
- actin filament
- microtubule
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding
- cytoskeletal adaptor activity
- actin binding
- microtubule binding