Ptpn14 Gene Summary [Mouse]
Predicted to enable protein tyrosine phosphatase activity; receptor tyrosine kinase binding activity; and transcription coregulator activity. Involved in lymphangiogenesis. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; musculoskeletal system; and sensory organ. Orthologous to human PTPN14 (protein tyrosine phosphatase non-receptor type 14). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptpn14 |
| Official Name | protein tyrosine phosphatase, non-receptor type 14 [Source:MGI Symbol;Acc:MGI:102467] |
| Ensembl ID | ENSMUSG00000026604 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase, non-receptor type 14 |
| Synonyms | C130080N23RIK, CATLPH, PEZ, protein tyrosine phosphatase non-receptor type 14, protein tyrosine phosphatase, non-receptor type 14, PTP36, PTPD2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptpn14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FERM central domain
- Band 4.1 homologues
- protein-tyrosine-phoshatase
- Protein tyrosine phosphatase, catalytic domain
- transcription cofactor
- linker domain
- protein binding
- Pleckstrin homology-like domain
- PTP_DSP_cys
- phosphatase domain
- zDHHC ankyrin repeat binding domain
- Protein tyrosine phosphatase, catalytic domain motif
- PTPase domain
- FERM N-terminal domain
- Dual specificity phosphatase, catalytic domain
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- Protein-tyrosine phosphatase
- receptor tyrosine kinase binding
- Ubl1_cv_Nsp3_N-like
- phosphatase
- FERM domain B-lobe
- FERM C-terminal PH-like domain
Pathways
Biological processes and signaling networks where the Ptpn14 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic lymphocytic leukemia
- epithelial cancer
- melanoma
- melanoma cancer
- skin basal cell carcinoma
- basal cell skin cancer
- liver cancer
- acute myeloid leukemia
- pancreatic adenocarcinoma
- pancreatic epithelial cancer
role in cell
- growth
- phosphorylation in
- activation in
- adhesion
- proliferation
- migration
- morphology
- quantity
- degranulation
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- cytoskeleton
- Nucleus
- Plasma Membrane
- membrane compartment
- intercellular junctions
- nucleoplasm
- anchoring junction
- membrane rafts
- cell-cell adherens junctions
- cytoskeletal fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptpn14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell proliferation
- protein dephosphorylation
- lymphangiogenesis
- regulation of protein export from nucleus
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoskeleton
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription cofactor activity
- protein binding
- protein tyrosine phosphatase activity
- receptor tyrosine kinase binding