Pde11a

Predicted to enable 3',5'-cyclic-nucleotide phosphodiesterase activity and cGMP binding activity. Predicted to be involved in cAMP-mediated signaling; negative regulation of cAMP-mediated signaling; and negative regulation of cGMP-mediated signaling. Predicted to be located in perikaryon. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; genitourinary system; and skeleton. Human ortholog(s) of this gene implicated in primary pigmented nodular adrenocortical disease 2. Orthologous to human PDE11A (phosphodiesterase 11A). [provided by Alliance of Genome Resources, Apr 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pde11a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Pde11a gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Pde11a gene, providing context for its role in the cell.