Pde11a Gene Summary [Rat]
Predicted to enable 3',5'-cyclic-nucleotide phosphodiesterase activity and cGMP binding activity. Involved in negative regulation of cAMP/PKA signal transduction and negative regulation of cGMP-mediated signaling. Located in perikaryon. Human ortholog(s) of this gene implicated in primary pigmented nodular adrenocortical disease 2. Orthologous to human PDE11A (phosphodiesterase 11A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pde11a |
| Official Name | phosphodiesterase 11A [Source:RGD Symbol;Acc:621793] |
| Ensembl ID | ENSRNOG00000024457 |
| Bio databases IDs | |
| Aliases | phosphodiesterase 11A |
| Synonyms | 6330414F14RIK, A630086N24, A630086N24Rik, Gm350, PDE11A1, phosphodiesterase 11A, Phosphodiesterase 11a2, PPNAD2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pde11a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Metal dependent phosphohydrolases with conserved 'HD' motif
- 3'5'-cyclic nucleotide phosphodiesterase
- cyclic-nucleotide phosphodiesterase
- cGMP-stimulated cyclic-nucleotide phosphodiesterase
- GAF domain
- enzyme
- HDc
- 3',5'-cyclic-nucleotide phosphodiesterase
- 3',5'-cGMP binding
- Domain present in phytochromes and cGMP-specific phosphodiesterases
Pathways
Biological processes and signaling networks where the Pde11a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- cognitive impairment
- major depression
- depressive disorder
- diabetic neuropathy
- peripheral neuropathy
- schizophrenia
- Parkinson disease
- adult solid tumor
- diabetes mellitus
regulated by
- tadalafil
- PRKG1
- dyphylline
- tolbutamide
- sildenafil
- dipyridamole
- pentoxifylline
- theophylline
- zaprinast
- NONO
role in cell
- activity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- cytosol
- perikaryon
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pde11a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- negative regulation of cGMP-mediated signaling
- negative regulation of cAMP-mediated signaling
- cAMP-mediated signaling
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
- metal ion binding
- 3',5'-cyclic-GMP phosphodiesterase activity
- cyclic-nucleotide phosphodiesterase activity
- cGMP binding
- 3',5'-cyclic-AMP phosphodiesterase activity
- 3',5'-cyclic-nucleotide phosphodiesterase activity